Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population?
Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population?
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DOI：
10.1111/febs.15303
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发表时间：
2020-03-28
期刊：
影响因子：
5.4
通讯作者：
Kabbani, Nadine
中科院分区：
文献类型：
--
作者：
Olds, James L.;Kabbani, Nadine
最近COVID-19的出现导致了一场全球性的危机，大量人口被封锁，交通联系被切断。虽然大约80%的感染者症状轻微，但大约15-20%的人需要住院治疗，这给全球医疗保健系统带来了巨大压力。截至3月10日，死亡率似乎约为3.4%，尽管这个数字在不同人群中高度分层。在这里，我们重点关注那些在接触病毒之前接触过尼古丁的人。我们预测，这些人是“准备”处于较高的风险，因为尼古丁可以直接影响病毒（ACE 2）的假定受体，并导致肺上皮细胞中的有害信号。
The recent emergence of COVID-19 has resulted in a worldwide crisis, with large populations locked down and transportation links severed. While approximately 80% of infected individuals have minimal symptoms, around 15-20% need to be hospitalized, greatly stressing global healthcare systems. As of March 10, the death rate appears to be about 3.4%, although this number is highly stratified among different populations. Here, we focus on those individuals who have been exposed to nicotine prior to their exposure to the virus. We predict that these individuals are 'primed' to be at higher risk because nicotine can directly impact the putative receptor for the virus (ACE2) and lead to deleterious signaling in lung epithelial cells.