Short-term timecourse of bilateral pudendal nerve injury on leak-point pressure in female rats
Short-term timecourse of bilateral pudendal nerve injury on leak-point pressure in female rats
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DOI：
10.1682/jrrd.2003.11.0169
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发表时间：
2005-01-01
影响因子：
--
通讯作者：
Damaser, MS
中科院分区：
文献类型：
--
作者：
Ahn, H;Lin, DL;Damaser, MS
阴部神经支配外尿道括约肌，受伤时可导致尿失禁。本实验旨在研究大鼠阴部神经挤压后尿道功能变化的时间过程。在双侧阴部神经受压2、4、7或14天后测量漏点压力（LPP），并与对照组进行比较。与对照组相比，神经损伤后四个时间点的LPP均显著降低。损伤后4天达到最小值，LPP随损伤后时间的延长呈上升趋势，提示神经功能可能开始恢复或尿道代偿性改变。阴部神经压迫导致雌性大鼠LPP下降，模仿应激性尿失禁的临床症状。当充分表征后，该模型可用于治疗和康复方案的临床前测试。
The pudendal nerve innervates the external urethral sphincter and, when injured, can contribute to incontinence development. This experiment was designed to study the time course of functional changes in the urethra after pudendal nerve crush in rats. Leak-point pressure (LPP) was measured 2, 4, 7, or 14 days after bilateral pudendal nerve crush and was compared to that of a control group. LPP at all four time points after nerve injury was significantly decreased compared to control values. A minimum was reached 4 days after injury and LPP appeared to trend upward with increasing time after in injury, suggesting that nerve function may begin to recover or compensatory changes in the urethra may occur. Pudendal nerve crush induces decreased LPP in female rats, mimicking the clinical symptoms of stress incontinence. When fully characterized, this model could be useful for preclinical testing of treatment and rehabilitation protocols.