Absent atherosclerotic risk factors are associated with carotid stiffening quantified with ultrafast ultrasound imaging
Absent atherosclerotic risk factors are associated with carotid stiffening quantified with ultrafast ultrasound imaging
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缺乏动脉粥样硬化危险因素与超快超声成像量化的颈动脉硬化相关
DOI：
10.1007/s00330-020-07405-4
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发表时间：
2020-10-17
影响因子：
5.9
通讯作者：
Huang, Hui
中科院分区：
文献类型：
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作者：
Zhu, Zheng-Qiu;Chen, Ling-Shan;Huang, Hui
目的用超快脉搏波速度(UfPWV)评价无常规心血管危险因素(CVRF)的受试者颈动脉硬化。该人群中的受试者被定义为当前非吸烟者，其血压和Lt； 140/90毫米汞柱，空腹血糖(FBG)和lt； 7.0mmoL/L，总胆固醇(TC)和lt； 6.2mmo1/L，低密度脂蛋白胆固醇(Lt)； 4.1mmoL/L和高密度脂蛋白胆固醇≥ 1.0mmolL/L。在CVRFs最佳亚组(CVRF-最佳亚组；n= 188)中，参与者定义为有血压<； 120/80 mmHg，TC和lt； 5.2 mm ol/L，Fbg<； 5.6 mm ol/L。临床问诊、体格检查、血常规、颈动脉内膜-中层厚度及超短型脉搏血流量。采用95%可信区间的调整优势比(OR)和有序Logistic回归模型。结果46.2-54.5%的无CVRF受试者存在颈动脉硬化。年龄、男性和体重指数与颈动脉硬化独立相关(年龄 = 为1.10-1.11，男性 = 为2.65-7.19，体重指数 = 为1.34-1.62；P<； 为0.05)。颈动脉硬化仅与TC相关(TC = 为1.84；p= 0.034)。动脉粥样硬化硬化的ufPWV有助于早期动脉粥样硬化的评估，并可能进一步阐明没有CVRF的健康成年人的真实状况。要点·CVRF优化的个体的颈动脉硬度低于无CVRF的人群。·ufPWV是AS早期评估的定量预测指标。·缺乏主要的CVRF不能被认为是颈动脉硬化和动脉粥样硬化的低风险因素。
ObjectivesTo evaluate carotid stiffening in participants without conventional cardiovascular risk factors (CVRFs) by using ultrafast pulse wave velocity (ufPWV).MethodsThe present study enrolled 517 participants without conventional CVRFs (CVRF-Free total population). Subjects in this population were defined as current non-smokers with untreated blood pressure < 140/90 mmHg, fasting blood glucose (FBG) < 7.0 mmol/L, total cholesterol (TC) < 6.2 mmol/L, low-density lipoprotein cholesterol < 4.1 mmol/L, and high-density lipoprotein cholesterol ≥ 1.0 mmol/L. Participants in the subgroup with optimal CVRFs (CVRF-Optimal subgroup;n= 188) were defined as having blood pressure < 120/80 mmHg, TC < 5.2 mmol/L, and FBG < 5.6 mmol/L. Clinical interviews, physical examinations, serum draw, carotid intima-media thickness (cIMT), and ufPWV were evaluated. Adjusted odds ratios (ORs) with 95% confidence intervals and ordinal logistic regression models were used.ResultsCarotid stiffening was present in 46.2–54.5% of CVRF-Free subjects. Age, male sex, and body mass index (BMI) were independently associated with carotid stiffening in both the CVRF-Free total population and CVRF-Optimal subgroup (OR for age = 1.10–1.11, OR for male sex = 2.65–7.19, OR for BMI = 1.34–1.62;p< 0.05). Carotid stiffening was associated with TC only in the CVRF-Free total population (OR for TC = 1.84;p= 0.034).ConclusionsMany CVRF-Free individuals have carotid stiffening. ufPWV for atherosclerotic stiffening aids the assessment of early atherogenesis and may further clarify the true status of healthy adults without CVRFs.Key Points•CVRF-Optimal individuals have a lower carotid stiffness than CVRF-Free populations.•ufPWV is a quantitative predictor for the early assessment of AS.•Absent major CVRFs cannot be considered low risk for carotid stiffening and atherosclerosis.