Pulmonary Vascular Lesions Are Common in SIV- and SHIV-env-Infected Macaques
Pulmonary Vascular Lesions Are Common in SIV- and SHIV-env-Infected Macaques
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DOI：
10.1089/aid.2009.0297
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发表时间：
2011-02-01
影响因子：
1.5
通讯作者：
Norris, Karen A.
中科院分区：
文献类型：
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作者：
George, M. Patricia;Brower, Alexandra;Norris, Karen A.
hiv相关性肺动脉高压（HIV-PAH）动物模型的缺乏严重限制了对这一严重疾病的研究。虽然HIV-PAH的组织学证据已在猕猴中得到证实。感染猴免疫缺陷病毒（SW）以及含有hiv -1衍生Nef蛋白的嵌合猴/人免疫缺陷病毒（SHIV），其他灵长类动物模型尚未研究。目的是记录和描述感染SW或含有hiv -1衍生包膜蛋白（SHIV-env）的SIV的猕猴肺血管变化的发展。从13只SHIV (89.6P)-env感染的猕猴和10只SIV （Delta B670）感染的猕猴尸检中获得肺组织。肺动脉病理，包括动脉增生和存在丛状病变，比较正常猴肺。13只感染shiv -env的猕猴中有8只（62%）出现肺动脉增生，10只感染siv的猕猴中有4只（36%）出现肺动脉增生。最常见的组织病理学病变是中、大肺动脉内膜和内侧增生。增生性病变主要是由于平滑肌细胞增生。这是首例在siv -env感染的猕猴中发现肺血管病变的报道，并证实了先前关于siv感染的猕猴肺血管病变的报道。在感染不含HIV-nef的SHIV的猴子中发现肺动脉病变，这表明其他因素可能在HIV-PAH的发展中也很重要。SHIV-env模型为HIV-PAH的研究提供了新的手段。
The lack of animal models of HIV-related pulmonary arterial hypertension (HIV-PAH) severely limits investigation of this serious disease. While histological evidence of HIV-PAH has been demonstrated in macaques. infected with simian immunodeficiency virus (SW) as well as with chimeric simian/human immunodeficiency virus (SHIV) containing HIV-1-derived Nef protein, other primate models have not been studied. The objective was to document and describe the development of pulmonary vascular changes in macaques infected with SW or with SIV containing HIV-1-derived envelope protein (SHIV-env). Lung tissue was obtained at necropsy from 13 SHIV (89.6P)-env-infected macaques and 10 SIV (Delta B670)-infected macaques. Pulmonary arterial pathology, including arterial hyperplasia and the presence of plexiform lesions, was compared to normal monkey lung. Pulmonary artery hyperplasia was present in 8 of 13 (62%) SHIV-env-infected macaques and 4/10 (36%) SIV-infected macaques. The most common histopathological lesions were intimal and medial hyperplasia of medium and large pulmonary arteries. Hyperplastic lesions were predominantly due to smooth muscle cell hyperplasia. This is the first report of pulmonary vascular lesions in SHIV-env-infected macaques and confirms prior reports of pulmonary vasculopathy in SIV-infected macaques. The finding of pulmonary arteriopathy in monkeys infected with SHIV not containing HIV-nef suggests that other factors might also be important in the development of HIV-PAH. This SHIV-env model provides a new means to investigate HIV-PAH.