Gabapentin acutely increases the apnea-hypopnea index in older men: data from a randomized, double-blind, placebo-controlled study
Gabapentin acutely increases the apnea-hypopnea index in older men: data from a randomized, double-blind, placebo-controlled study
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DOI：
10.1111/jsr.12495
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发表时间：
2017-04-01
影响因子：
4.4
通讯作者：
Poyares, Dalva
中科院分区：
文献类型：
--
作者：
Piovezan, Ronaldo D.;Kase, Camila;Poyares, Dalva
虽然具有镇静作用的药物可能增加睡眠期间气道塌陷的风险，但其对老年人呼吸暂停低通气指数的急性影响报道不足。我们研究了加巴喷丁（GABA）对无睡眠呼吸暂停的老年男性睡眠呼吸的急性影响。在8名非肥胖老年男性中进行了一项双盲、随机、安慰剂对照、交叉试验研究，使用睡前剂量的加巴喷丁300 mg。多导睡眠图测量干预的效果。加巴喷丁组的呼吸暂停低通气指数高于安慰剂组（22.4 ± 6.1 vs 12.2 ± 4.3，P
Although drugs with sedative properties may increase the risk of airway collapse during sleep, their acute effects on the apnea-hypopnea index in older adults are under-reported. We investigated the acute effects of gabapentin (GABA) on sleep breathing in older men without sleep apnea. A double-blind, randomized, placebo-controlled cross-over pilot study using a bedtime dose of gabapentin 300 mg was conducted in eight non-obese older men. Polysomnography measured the effects of the intervention. The apnea-hypopnea index was higher in the gabapentin arm than in the placebo arm (22.4 +/- 6.1 versus 12.2 +/- 4.3, P