Curcumin as a DNA topoisomerase II poison
Curcumin as a DNA topoisomerase II poison
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DOI：
10.1080/14756360310001613085
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发表时间：
2003-12-01
影响因子：
5.6
通讯作者：
Ayuso, MJ
中科院分区：
文献类型：
--
作者：
Martín-Cordero, C;López-Lázaro, M;Ayuso, MJ
姜黄素是香料姜黄的主要活性成分，被认为是一种安全的化合物，在癌症化学预防和癌症治疗方面具有巨大潜力。它诱导细胞凋亡，但其启动机制仍然知之甚少。姜黄素对人癌细胞系TK-10、MCF-7和UACC-62的IC 50值分别为12.16、3.63、4.28 μ M。还研究了该化合物作为拓扑异构酶II毒物的可能性，发现50 μ M姜黄素以类似于抑制剂依托泊苷的方式具有活性。这些结果表明，拓扑异构酶II中毒诱导的DNA损伤作为姜黄素启动细胞凋亡的可能机制，并增加了表明其可能用于癌症治疗的证据。
Curcumin, the major active component of the spice turmeric, is recognised as a safe compound with great potential for cancer chemoprevention and cancer therapy. It induces apoptosis, but its initiation mechanism remains poorly understood. Curcumin has been assessed on the human cancer cell lines, TK-10, MCF-7 and UACC-62, and their IC50 values were 12.16, 3.63, 4.28 muM respectively. The possibility of this compound being a topoisomerase II poison has also been studied and it was found that 50 muM of curcumin is active in a similar fashion to the antineoplastic agent etoposide. These results point to DNA damage induced by topoisomerase II poisoning as a possible mechanism by which curcumin initiates apoptosis, and increase the evidence suggesting its possible use in cancer therapy.