EFFECTS OF IMMUNOSUPPRESSION ON AVIAN COCCIDIOSIS - CYCLOSPORINE-A BUT NOT HORMONAL BURSECTOMY ABROGATES HOST PROTECTIVE IMMUNITY
EFFECTS OF IMMUNOSUPPRESSION ON AVIAN COCCIDIOSIS - CYCLOSPORINE-A BUT NOT HORMONAL BURSECTOMY ABROGATES HOST PROTECTIVE IMMUNITY
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DOI：
10.1128/iai.55.7.1616-1621.1987
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发表时间：
1987-07-01
影响因子：
3.1
通讯作者：
LILLEHOJ, HS
中科院分区：
文献类型：
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作者：
LILLEHOJ, HS
本试验研究了环孢菌素A（CsA）治疗和激素性法氏囊切除对鸡柔嫩艾美耳球虫（Eimeria tenella）感染的影响，以探讨体液抗体和细胞免疫在鸡球虫病保护性免疫中的作用。激素性法氏囊切除对宿主对E. tenella。CsA治疗对病程有不同的影响，这取决于CsA相对于感染的给药方式。在初次感染E.与未处理的对照相比，tenella增强了抗病性，而在初次感染前给予单剂量CsA增强了疾病易感性。在初次感染期间用CsA处理的鸡在初次感染后5周抵抗再感染。免疫鸡的治疗。尽管存在高水平的球虫特异性分泌免疫球蛋白A和血清免疫球蛋白G，但在二次感染时CsA消除了它们对再感染的抵抗力。CsA处理后获得的脾淋巴细胞表现出显着抑制刀豆球蛋白A的反应，但不是一个压抑的脂多糖反应。由于CsA在继发感染期间给药时对体内寄生虫没有直接毒性，因此这些结果表明CsA与免疫系统相互作用以允许在感染期间引发，同时在继发感染期间干扰CMI的效应器功能。综上所述，目前的研究结果表明，CMI在宿主对E. tenella。
The effects of cyclosporin A (CsA) treatment and hormonal bursectomy on Eimeria tenella infection of chickens were investigated to evaluate the role of humoral antibody and cell-mediated immunity (CMI) in the host protective immunity to an intestinal protozoan disease, coccidiosis. Hormonal bursectomy had no significant effect on the host response to E. tenella. CsA treatment had a differential effect on the course of disease depending on how CsA was given relative to infection. Daily administration of CsA for 7 days beginning 1 day before primary infection with E. tenella enhanced disease resistance, whereas a single dose of CsA given before primary infection enhanced disease susceptibility compared with that of untreated controls. Chickens treated with CsA during the primary infection were resistant to reinfection at 5 weeks post-primary infection. Treatment of chickens immune to E. tenella with CsA at the time of secondary infection abrogated their resistance to reinfection despite the presence of high levels of coccidia-specific secretory immunoglobulin A and serum immunoglobulin G. Splenic lymphocytes obtained after CsA treatment demonstrated a substantially depressed concanavalin A response, but not a depressed lipopolysaccharide response. Because CsA was not directly toxic to parasites in vivo when administered during the secondary infection, these results suggest that CsA interacts with the immune system to allow priming during the infection, while interfering while the effector function of CMI during the secondary infection. Taken together, present findings indicate that CMI plays a major role in host protective immunity to E. tenella.