Endocrine-disrupting chemicals and skin manifestations
Endocrine-disrupting chemicals and skin manifestations
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内分泌干扰化学物质和皮肤表现
DOI：
10.1007/s11154-016-9371-2
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发表时间：
2016-09-01
影响因子：
8.2
通讯作者：
Zouboulis, Christos C.
中科院分区：
文献类型：
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作者：
Ju, Qiang;Zouboulis, Christos C.
内分泌干扰物（Endocrine-disrupting chemicals，EDCs）是一种能够通过与激素受体直接或间接相互作用干扰激素产生和作用的外源性化合物，可作为激动剂或拮抗剂发挥作用。人体健康受到影响后，无论是个人的职业或饮食和环境暴露于内分泌干扰物。另一方面，皮肤是人体最大的器官之一，其主要功能是保护人体免受有害物质的侵害。内分泌干扰物干扰内分泌系统，并且它们也对人类皮肤具有致癌性、免疫毒性和肝毒性。此外，它们对角质形成细胞、黑素细胞、皮脂腺细胞、炎性和免疫细胞以及皮肤干细胞的作用产生炎性和过敏性皮肤病、氯痤疮、皮肤色素沉着病症、皮肤癌和皮肤老化。内分泌干扰物用于诱导这些皮肤疾病的机制是复杂的，并且涉及内源性激素的干扰，最重要的是芳烃受体信号通路的激活。需要进一步研究内分泌干扰物和皮肤疾病来阐明这些机制。
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that have the ability to disrupt the production and actions of hormones through direct or indirect interaction with hormone receptors, thus acting as agonists or antagonists. Human health is affected after either individual occupation or dietary and environmental exposure to EDCs. On the other hand, skin is one of the largest organs of the body and its main function is protection from noxious substances. EDCs perturb the endocrine system, and they are also carcinogenic, immunotoxic, and hepatotoxic to human skin. In addition, their effects on keratinocytes, melanocytes, sebocytes, inflammatory and immunological cells, and skin stem cells produce inflammatory and allergic skin diseases, chloracne, disorders of skin pigmentation, skin cancer, and skin aging. Mechanisms, which EDCs use to induce these skin disorders are complicated, and involve the interference of endogenous hormones and most importantly the activation of the aryl hydrocarbon receptor signal pathway. Further studies on EDCs and skin diseases are necessary to elucidate these mechanisms.