Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis
Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis
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DOI：
10.1053/jhep.2002.33324
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发表时间：
2002-06-01
期刊：
影响因子：
13.5
通讯作者：
Poynard, T
中科院分区：
文献类型：
--
作者：
Ratziu, V;Bonyhay, L;Poynard, T
尽管肥胖和糖尿病的发病率在上升，但很少有人强调肥胖相关的肝硬变的发病率和死亡率，这通常被认为是一种罕见的无症状情况。我们的目的是评估与其他原因的肝硬变相比，肥胖相关的隐源性肝硬变的存活率、肝细胞癌和肝功能不全并发症的发生情况。对27例超重隐源性肝硬变(CC-O)、10例消瘦隐源性肝硬变(CC-L)和391例丙型肝炎病毒相关性肝硬变(C-丙型肝炎)患者进行了回顾性分析。在CC-O患者中，比丙型丙型肝炎和CC-L患者更晚发现肝硬变。严重的肝病在CC-O患者中与在C-丙型肝炎患者中一样常见，从ChildB或C或肝脏失代偿发作的比例可以看出。CC-O患者的存活率低于未经治疗、年龄和性别匹配的丙型肝炎患者(P
Despite the rising incidence of obesity and diabetes, there is little emphasis on morbidity and mortality from obesity-related cirrhosis, usually considered a rare and asymptomatic condition. Our aim was to assess survival and the occurrence of hepatocellular carcinoma and complications of hepatic insufficiency in obesity-related cryptogenic cirrhosis compared with cirrhosis of other origins. We analyzed retrospectively 27 overweight patients with cryptogenic cirrhosis (CC-O), 10 lean patients with cryptogenic cirrhosis (CC-L) and 391 patients with hepatitis C virus-related cirrhosis (C-HCV). In CC-O patients, cirrhosis was detected later in life than in C-HCV and CC-L patients. Severe liver disease was as frequent in CC-O as in C-HCV patients as indicated by the proportion of Child B or C or of episodes of hepatic decompensation. Survival of CC-O patients was lower than that of untreated, age-and sex-matched C-HCV controls (P