Lesions of the subfornical organ block angiotensin-induced drinking in the dog.
Lesions of the subfornical organ block angiotensin-induced drinking in the dog.
复制标题
穹窿下器官的病变会阻碍狗血管紧张素诱导的饮酒。
DOI：
10.1159/000123357
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发表时间：
1982
影响因子：
4.1
通讯作者：
Ramsay,DJ
中科院分区：
文献类型：
--
作者：
Thrasher,TN;Simpson,JB;Ramsay,DJ
研究了穹窿下器官（SFO）在细胞脱水和血管紧张素引起的饮水中的作用。比较电解消融SFO前后静脉注射血管紧张素和高渗NaCl的饮水反应。SFO破坏后，血管紧张素引起的饮水量为0.5 ± 0.3 ml/kg，而损伤前为11.9 ± 3.7 ml/kg。SFO损伤对高渗NaCl引起的饮水反应没有影响（损伤前为12.6 ± 6.6 ml/kg，损伤后为13.4 ± 5.4 ml/kg）。病变上级或侧面的SFO并没有影响饮酒的血管紧张素或高渗氯化钠。这些数据表明，SFO是必不可少的饮用响应于血液传播的血管紧张素，但不是在狗的细胞脱水的刺激。
The role of the subfornical organ (SFO) in drinking caused by cellular dehydration and angiotensin was examined in the dog. Drinking responses to intravenous administration of angiotensin and to hypertonic NaCl were compared before and after electrolytic ablation of the SFO. After destruction of the SFO, drinking in response to angiotensin was 0.5 ± 0.3 ml/kg compared to 11.9 ± 3.7 ml/kg prior to lesioning. Drinking in response to hypertonic NaCl was not affected by lesioning the SFO (12.6 ± 6.6 ml/kg before vs. 13.4 ± 5.4 ml/kg after the lesion). Lesions superior or lateral to the SFO did not affect drinking in response to either angiotensin or hypertonic NaCl. These data show that the SFO is essential for drinking in response to blood-borne angiotensin but not to the stimulus of cellular dehydration in the dog.