Using neurophysiological markers of genetic risk to define the boundaries of the schizophrenia spectrum phenotype
Using neurophysiological markers of genetic risk to define the boundaries of the schizophrenia spectrum phenotype
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DOI：
10.1093/oxfordjournals.schbul.a007006
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发表时间：
2003-01-01
影响因子：
6.6
通讯作者：
Thaker, GK
中科院分区：
文献类型：
--
作者：
Avila, MT;Adami, HM;Thaker, GK
有相当多的证据表明，精神分裂症谱系人格障碍标志着精神分裂症的遗传风险。在遗传学和神经生理学研究中使用光谱表型可能被证明是有用的。然而，目前的诊断标准在多大程度上符合遗传风险尚不清楚。这可以通过观察SSP受试者的责任衡量标准如何随着诊断标准的变化而变化来评估。在这项研究中，使用广义估计方程方法来评估SSP和非SSP家族在眼动跟踪性能上的变化。以及使用各种诊断标准的社区团体。在逐渐更加宽松的SSP标准下，SSP亲属的眼球跟踪缺陷与其他组相比，在统计学上仍然更高。结果表明，比临床诊断中使用的更少的性状可以有效地识别精神分裂症患者亲属的谱型。因此，在研究中可以使用降低的标准来增加“高危”样本的大小和检测神经生理和遗传差异的能力。我们的结果提供了提示性证据，表明在研究中使用临床标准可能实际上低估了高危个体-潜在地扭曲了遗传和神经生理学发现。
There is considerable evidence that schizophrenia spectrum personality (SSP) disorders mark genetic risk for schizophrenia. Use of the spectrum phenotype in genetic and neurophysiological studies may prove informative. However, the degree to which the current diagnostic criteria correspond with genetic risk is unclear. This can be assessed by observing how measures of liability among SSP subjects change as a function of diagnostic criteria. In this study the generalized estimating equation method was used to assess changes in eye-tracking performance among SSP and non-SSP family. and community groups employing various diagnostic criteria. Eye-tracking deficits among SSP relatives remained statistically higher compared with the other groups across progressively more liberal SSP criteria. The results suggest that fewer traits than are used in clinical diagnoses can effectively identify the spectrum phenotype among relatives of schizophrenia patients. Thus, reduced criteria may be used in research to increase "high risk" sample size and power to detect neurophysiological and genetic differences. Our results provide suggestive evidence that the use of clinical criteria in research may, in fact, underidentify at-risk individuals-potentially distorting genetic and neurophysiological findings.