Effects of alendronate on particle-induced osteolysis in a rat model
Effects of alendronate on particle-induced osteolysis in a rat model
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DOI：
10.2106/00004623-200202000-00011
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发表时间：
2002-02-01
影响因子：
5.3
通讯作者：
Bostrom, MPG
中科院分区：
文献类型：
--
作者：
Millett, PJ;Allen, MJ;Bostrom, MPG
背景：颗粒诱导的骨溶解是目前影响全关节置换术长期生存的主要问题。阿仑膦酸盐是第三代双磷酸盐，可阻断骨细胞的骨吸收。本研究的目的是确定阿仑膦酸钠是否可以防止颗粒诱导的骨质溶解或恢复（逆转）骨丢失在建立osteolysis.Methods：颗粒诱导的骨质溶解的大鼠模型。在72只动物的右胫骨近端放置一个特殊设计的聚乙烯植入物。经过4周的愈合后，将动物随机分为对照组、预防组或治疗组。在预防组中，动物接受关节内注射高密度聚乙烯颗粒（平均尺寸，2 μ m;所有
Background: Particle-induced osteolysis is currently a major problem affecting the long-term survivorship of total joint replacements. Alendronate is a third-generation bisphosphonate that blocks osteoclastic bone resorption. The objective of this study was to determine whether alendronate could prevent particle-induced osteolysis or restore (reverse) bone loss in established osteolysis.Methods: A rat model of particle-induced osteolysis was used. A specially designed polyethylene implant was placed in the proximal part of the right tibia of seventy-two animals. Following four weeks of healing, the animals were randomized into control groups, a prevention group, or a treatment group. In the prevention group, animals received intra-articular injections of high-density polyethylene particles (mean size, 2 mum; all