Cu(I)-catalyzed enantioselective [3+2] cycloaddition reaction of 1-alkylallenylsilane with α-imino ester:: Asymmetric synthesis of dehydroproline derivatives
Cu(I)-catalyzed enantioselective [3+2] cycloaddition reaction of 1-alkylallenylsilane with α-imino ester:: Asymmetric synthesis of dehydroproline derivatives
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DOI：
10.1021/ol047343c
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发表时间：
2005-03-17
期刊：
影响因子：
5.2
通讯作者：
Akiyama, T
中科院分区：
文献类型：
--
作者：
Daidouji, K;Fuchibe, K;Akiyama, T
采用[Cu(MeCN)(4)]BF4/(R)-DM-SEGPHOS催化剂，实现了1-烷基取代烯基硅烷与α -亚胺酯的对映选择性[3 + 2]环加成反应，得到了高收率和对映选择性的硅基取代脱氢脯氨酸衍生物。
The catalytic, enantioselective [3 + 2] cycloaddition reaction of 1-alkyl-substituted allenylsilanes with alpha-imino ester has been achieved by means of [Cu(MeCN)(4)]BF4/(R)-DM-SEGPHOS catalyst to afford silyl-substituted dehydroproline derivatives in high yields and enantioselectivities.