Method for rapid MRI quantification of global cerebral metabolic rate of oxygen
Method for rapid MRI quantification of global cerebral metabolic rate of oxygen
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DOI：
10.1038/jcbfm.2015.96
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发表时间：
2015-10-01
影响因子：
6.3
通讯作者：
Wehrli, Felix W.
中科院分区：
文献类型：
--
作者：
Barhoum, Suliman;Langham, Michael C.;Wehrli, Felix W.
最近报道的一种定量磁共振成像（MRI）方法OxFlow已被证明能够通过同时测量30秒内上矢状窦的氧饱和度（SvO2）和大脑动脉的脑血流量（CBF）来量化全脑脑氧代谢率（cmoro2），这对于基线测量是足够的，但不一定是对神经元激活的反应。在这里，我们提出了一种加速版本的方法（称为F-OxFlow），在完全保留父方法的能力的情况下，在8秒的扫描时间内量化CMRO2，并将其与10名健康受试者的基线值进行比较。结果表明，两个序列之间的一致性非常好，SvO2、CBF和cmor2的平均偏倚分别为2.2% （P = 0.18，双尾t检验）、3.4% （P = 0.08，双尾t检验）和2.0% （P = 0.56，双尾t检验）。F-OxFlow在监测SvO2、CBF和cmoro2动态变化方面的潜力在一项应用于5名研究对象的自愿性呼吸暂停范例中得到了说明。该序列捕获的SvO2、CBF和cmoro2的平均增幅分别为10.1 +/- 2.5%、43.2 +/- 9.2%和7.1 +/- 2.2%，与文献值吻合良好。因此，该方法可能适用于监测CBF和SvO2在神经血管刺激下的变化。
A recently reported quantitative magnetic resonance imaging (MRI) method denoted OxFlow has been shown to be able to quantify whole-brain cerebral metabolic rate of oxygen (CMRO2) by simultaneously measuring oxygen saturation (SvO2) in the superior sagittal sinus and cerebral blood flow (CBF) in the arteries feeding the brain in 30 seconds, which is adequate for measurement at baseline but not necessarily in response to neuronal activation. Here, we present an accelerated version of the method (referred to as F-OxFlow) that quantifies CMRO2 in 8 seconds scan time under full retention of the parent method's capabilities and compared it with its predecessor at baseline in 10 healthy subjects. Results indicate excellent agreement between both sequences, with mean bias of 2.2% (P = 0.18, two-tailed t-test), 3.4% (P = 0.08, two-tailed t-test), and 2.0% (P = 0.56, two-tailed t-test) for SvO2, CBF, and CMRO2, respectively. F-OxFlow's potential to monitor dynamic changes in SvO2, CBF, and CMRO2 is illustrated in a paradigm of volitional apnea applied to five of the study subjects. The sequence captured an average increase in SvO2, CBF, and CMRO2 of 10.1 +/- 2.5%, 43.2 +/- 9.2%, and 7.1 +/- 2.2%, respectively, in good agreement with literature values. The method may therefore be suited for monitoring alterations in CBF and SvO2 in response to neurovascular stimuli.