MECHANSIM OF DNA CHAIN GROWTH .I. POSSIBLE DISCONTINUITY AND UNUSUAL SECONDARY STRUCTURE OF NEWLY SYNTHESIZED CHAINS
MECHANSIM OF DNA CHAIN GROWTH .I. POSSIBLE DISCONTINUITY AND UNUSUAL SECONDARY STRUCTURE OF NEWLY SYNTHESIZED CHAINS
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DOI：
10.1073/pnas.59.2.598
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发表时间：
1968-01-01
影响因子：
11.1
通讯作者：
SUGINO, A
中科院分区：
文献类型：
--
作者：
OKAZAKI, R;OKAZAKI, T;SUGINO, A
大多数最近合成的染色体部分可以在变性后作为小DNA分子获得，其在各种细菌系统和1种噬菌体系统中的沉降系数约为10S。这支持了2个子链以不连续的方式合成的机制。含有这些新合成的链的染色体区域的二级结构可能不同于普通的双链DNA。
Most of the recently synthesized portion of the chromosome can be obtained after denaturation as small DNA molecules with a sedimentation coefficient of about 10S in a variety of bacterial systems and in 1 bacteriophage system. This supports the mechanism that 2 daughter strands are synthesized in a discontinuous fashion. The secondary structure of the chromosomal region containing these newly synthesized chains may differ from that of ordinary double-stranded DNA.