Auditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia
Auditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia
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DOI：
10.1177/1550059420914201
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发表时间：
2020-03-23
影响因子：
2
通讯作者：
Spencer, Kevin M.
中科院分区：
文献类型：
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作者：
Hirano, Yoji;Oribe, Naoya;Spencer, Kevin M.
我们研究了初级听觉皮层（Heschl's gyrus [HG]）的灰质体积是否与精神分裂症患者听觉γ活动的异常模式相关，即40 Hz听觉稳态反应（ASSR）中γ同步受损和自发宽带γ功率增加。(Theγ数据先前在Hirano等人，JAMA Psychiatry，2015;72：813-821中报道）。参与者是24名健康对照（HC）和23名慢性精神分裂症患者（SZ）。ASSR由20、30和40 Hz频率的短声串刺激的脑电图获得。偶极子源定位的ASSR被用来提供一个空间滤波器的听觉皮层活动，从ASSR诱发功率和相位锁定因子（PLF），和诱发伽玛功率计算。HG灰质体积来自3 T下的结构磁共振成像，手动追踪感兴趣区域。正如预期的那样，与HC相比，SZ中的HG灰质体积减少。在SZ，左半球ASSR PLF和诱导伽玛功率在40 Hz刺激条件下，正相关和负相关的左侧HG灰质体积，分别。这些结果提供的证据表明，皮质灰质结构，可能导致在微电路水平的突触连接减少，与受损的γ同步和增加自发γ活动的精神分裂症。
We investigated whether the gray matter volume of primary auditory cortex (Heschl's gyrus [HG]) was associated with abnormal patterns of auditory gamma activity in schizophrenia, namely impaired gamma synchronization in the 40-Hz auditory steady-state response (ASSR) and increased spontaneous broadband gamma power. (The gamma data were previously reported in Hirano et al, JAMA Psychiatry, 2015;72:813-821). Participants were 24 healthy controls (HC) and 23 individuals with chronic schizophrenia (SZ). The ASSR was obtained from the electroencephalogram to click train stimulation at 20, 30, and 40 Hz rates. Dipole source localization of the ASSR was used to provide a spatial filter of auditory cortex activity, from which ASSR evoked power and phase locking factor (PLF), and induced gamma power were computed. HG gray matter volume was derived from structural magnetic resonance imaging at 3 T with manually traced regions of interest. As expected, HG gray matter volume was reduced in SZ compared with HC. In SZ, left hemisphere ASSR PLF and induced gamma power during the 40-Hz stimulation condition were positively and negatively correlated with left HG gray matter volume, respectively. These results provide evidence that cortical gray matter structure, possibly resulting from reduced synaptic connectivity at the microcircuit level, is related to impaired gamma synchronization and increased spontaneous gamma activity in schizophrenia.