Aerobic capacity and skeletal muscle function in children with asthma
Aerobic capacity and skeletal muscle function in children with asthma
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哮喘儿童的有氧能力和骨骼肌功能
DOI：
10.1136/adc.2011.212431
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发表时间：
2011
影响因子：
5.2
通讯作者：
C. Carvalho
中科院分区：
文献类型：
--
作者：
Fabiane Villa;A. Castro;A. Pastorino;J. M. Santarém;M. Martins;C. Jacob;C. Carvalho
背景慢性肺部疾病患者外周肌肉力量和耐力下降，似乎是导致患者运动不耐受的原因。然而，作者不知道有任何研究评估哮喘儿童的外周肌肉功能。这似乎意味着哮喘儿童的有氧适应性较低，但比较哮喘儿童和非哮喘儿童有氧能力的研究有限。本研究旨在评估持续性哮喘儿童的肌肉力量和耐力及其与有氧能力和吸入性皮质类固醇消耗的关系。方法对40例轻度持续性哮喘（MPA）和重度持续性哮喘（SPA）患儿（各20例）和20例非哮喘患儿（对照组）进行评估。评估上（胸肌和背阔肌）和下（四头肌）肌肉力量和耐力，并进行心肺运动试验。还量化了过去6个月和24个月期间吸入皮质类固醇的消耗量。结果SPA患儿的最大耗氧量（VO2）降低，（28.2 ± 8.1 vs 34.7 ± 6.9 ml/kg/min; p <0.01）和股四头肌耐力（43.1 ± 6.7 vs 80.9 ± 11.9次重复; p <0.05）与对照组相比，但与MPA组无关（31.5 ± 6.1 ml/kg/min和56.7 ± 47.7次; p> 0.05）。轻度和重度哮喘儿童的最大上、下肌力均得到了保留（p> 0.05）。最后，作者观察到，在哮喘儿童中，较低的肌肉耐力虚弱与峰值VO2（r = 0.22，p> 0.05）或皮质类固醇消耗（r =-0.31，p> 0.05）的减少无关。结论重症哮喘儿童的体能训练应优先考虑心肺功能锻炼和下肢肌肉耐力训练。
Background Peripheral muscle strength and endurance are decreased in patients with chronic pulmonary diseases and seem to contribute to patients' exercise intolerance. However, the authors are not aware of any studies evaluating peripheral muscle function in children with asthma. It seems to be implied that children with asthma have lower aerobic fitness, but there are limited studies comparing the aerobic capacity of children with and without asthma. The present study aimed to evaluate muscle strength and endurance in children with persistent asthma and their association with aerobic capacity and inhaled corticosteroid consumption. Methods Forty children with mild persistent asthma (MPA) or severe persistent asthma (SPA) (N=20 each) and 20 children without asthma (control group) were evaluated. Upper (pectoralis and latissimus dorsi) and lower (quadriceps) muscle strength and endurance were assessed, and cardiopulmonary exercise testing was performed. Inhaled corticosteroid consumption during the last 6 and 24 months was also quantified. Results Children with SPA presented a reduction in peak oxygen consumption (VO2) (28.2±8.1 vs 34.7±6.9 ml/kg/min; p<0.01) and quadriceps endurance (43.1±6.7 vs 80.9±11.9 repetitions; p<0.05) compared with the control group, but not the MPA group (31.5±6.1 ml/kg/min and 56.7±47.7 repetitions respectively; p>0.05). Maximal upper and lower muscle strength was preserved in children with both mild and severe asthma (p>0.05). Finally, the authors observed that lower muscle endurance weakness was not associated with reductions in either peak VO2 (r=0.22, p>0.05) or corticosteroid consumption (r=−0.31, p>0.05) in children with asthma. Conclusion The findings suggest that cardiopulmonary exercise and lower limb muscle endurance should be a priority during physical training programs for children with severe asthma.
自行车测力治疗后严重哮喘儿童的心肺耐力正常化。
DOI：
10.1016/s0022-3476(86)80115-9
发表时间：
1986
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Ludwick,SK;Jones,JW;Jones,TK;Fukuhara,JT;Strunk,RC
通讯作者：
Strunk,RC