Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children
Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children
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DOI：
10.1016/s0022-3476(99)70053-3
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发表时间：
1999-11-01
影响因子：
5.1
通讯作者：
Young, RJ
中科院分区：
文献类型：
--
作者：
Vanderhoof, JA;Whitney, DB;Young, RJ
目的：研究干酪乳杆菌（Lactobacillus casei sps）的抗菌效果。研究设计：202名6个月至10岁的儿童参加了研究，188名儿童完成了所有阶段的研究方案。在一项双盲随机试验中，在门诊接受口服抗生素治疗的儿童中给予LGG，每天1 × 10（10）- 2 × 10（10）菌落形成单位，或相当的安慰剂。主要照顾者每3天询问一次胃肠道症状的发生率，主要是粪便的频率和一致性，通过电话联系由盲investigator.Results：25安慰剂治疗，但只有7 LGG治疗的患者腹泻定义为液体粪便编号2或更大的每一天。乳酸杆菌GG整体显着减少大便频率和增加粪便一致性抗生素治疗期间的第十天相比，安慰剂group.Conclusion：乳酸杆菌GG减少腹泻相关的儿童常见的儿童感染口服抗生素治疗的发病率。
Objective: The objective of this study was to determine the efficacy of Lactobacillus casei sps. rhamnosus (Lactobacillus GG) (LGG) in reducing the incidence of antibiotic-associated diarrhea when coadministered with an oral antibiotic in children with acute infectious disorders.Study design: Two hundred two children between 6 months and 10 years of age were enrolled; 188 completed all phases of the protocol. LGG, 1 x 10(10) - 2 x 10(10) colony forming units per day, or comparable placebo was administered in a double-blind randomized trial to children receiving oral antibiotic therapy in an outpatient setting. The primary caregiver was questioned every 3 days regarding the incidence of gastrointestinal symptoms, predominantly stool frequency and consistency, through telephone contact by blinded investigators.Results: Twenty-five placebo-treated but only 7 LGG-treated patients had diarrhea as defined by liquid stools numbering 2 or greater per day. Lactobacillus GG overall significantly reduced stool frequency and increased stool consistency during antibiotic therapy by the tenth day compared with the placebo group.Conclusion: Lactobacillus GG reduces the incidence of antibiotic-associated diarrhea in children treated with oral antibiotics for common childhood infections.