NEUROANATOMICAL SUBSTRATES OF DEPRESSION IN THE ELDERLY
NEUROANATOMICAL SUBSTRATES OF DEPRESSION IN THE ELDERLY
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DOI：
10.1007/bf02191522
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发表时间：
1993-07-01
影响因子：
4.7
通讯作者：
ELLINWOOD, EH
中科院分区：
文献类型：
--
作者：
KRISHNAN, KRR;MCDONALD, WM;ELLINWOOD, EH
老年人抑郁症的病因尚不清楚。在这项研究中，磁共振成像评估皮层下结构在老年抑郁症病理生理中的作用。老年抑郁症患者的尾状核更小，壳层复合体更小，皮质下高信号的频率也比正常的健康对照者高。这些发现在迟发性抑郁症患者中更为明显。基于这些发现，作者讨论了基底神经节在老年抑郁症病理生理中的作用。
The etiology of depression in the elderly is poorly understood. In this study, magnetic resonance imaging was used to evaluate the role of subcortical structures in the pathophysiology of depression in the elderly. Elderly depressed patients were found to have smaller caudate nuclei, smaller putaminal complexes and in increased frequency of subcortical hyperintensities compared with normal, healthy controls. These findings were more pronounced in patients with late-onset depression. Based on these findings, the authors discuss the role of the basal ganglia in the pathophysiology of depression in the elderly.