Synthesis of Stable Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging
Synthesis of Stable Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging
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DOI：
10.1021/acs.langmuir.6b01867
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发表时间：
2016-10-25
期刊：
影响因子：
3.9
通讯作者：
Kolios, Michael C.
中科院分区：
文献类型：
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作者：
Fernandes, Donald A.;Fernandes, Dennis D.;Kolios, Michael C.
纳米技术为药物输送提供了一个很有前途的平台。纳米结构材料可以被设计成具有所需的超顺磁性或荧光性质，并结合生物化学功能化部分（即，抗体、肽和小分子）以主动结合靶位点。这些多功能特性使它们成为多模式成像、诊断和治疗的合适试剂。全氟己烷纳米乳剂（PFH-NEs）是一种新型的药物递送载体和造影剂，用于体内癌症的超声和光声成像，与传统的光学技术相比，具有更高的空间分辨率和更深的组织穿透力。与其他治疗诊断剂相比，我们的PFH-NE是同类产品中最小的（
Nanotechnology provides a promising platform for drug-delivery in medicine. Nanostructured materials can be designed with desired super paramagnetic or fluorescent properties in conjunction with biochemically functionalized moieties (i.e., antibodies, peptides, and small molecules) to actively bind to target sites. These multifunctional properties make them suitable agents for multimodal imaging, diagnosis, and therapy. Perfluorohexane nanoemulsions (PFH-NEs) are novel drug-delivery vehicles and contrast agents for ultrasound and photoacoustic imaging of cancer in vivo, offering higher spatial resolution and deeper penetration of tissue when compared to conventional optical techniques. Compared to other theranostic agents, our PFH-NEs are one of the smallest of their kind (