Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery.
Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery.
复制标题
口服药物输送系统包括改变的几何构型，用于受控药物输送。
DOI：
10.3390/ijms13010018
复制
发表时间：
2012
影响因子：
5.6
通讯作者：
Bawa P
中科院分区：
文献类型：
--
作者：
Moodley K;Pillay V;Choonara YE;du Toit LC;Ndesendo VM;Kumar P;Cooppan S;Bawa P
最近的药学研究集中在受控给药方面，它比传统方法具有优势。这些系统可能提供的一些好处是，足够的受控血浆药物水平、减少的副作用以及改善患者的依从性。能够提供零级给药的受控给药系统有可能在最大限度地提高疗效的同时将剂量、频率和毒性降至最低。因此，零级药物释放在大范围的药物输送中是理想的，因此导致了具有这种药物释放模式的各种技术的发展。多层平板电脑和其他几何变化设备等系统已经被创造出来，以执行这一功能。多层片剂的原理之一是为释放创造一个恒定的表面积。聚合物材料在这些系统的功能中扮演着重要的角色。迄今为止开发的技术包括：Geomatrix®多层片剂，它利用特定的聚合物作为药物释放的屏障；Procise®，其核心具有可修改的孔，以实现各种类型的药物释放；核心杯片剂，其核心骨架覆盖在一个表面，周围形成一个杯子；甜甜圈形状的装置，具有中央放置的孔洞和Dome Matrix®以及“释放模块组件”，可以提供不同的药物释放模式。本文讨论了用于提供药物控制释放的新型改变的几何体系技术，并重点介绍了在这类开发中使用的聚合物。
Recent pharmaceutical research has focused on controlled drug delivery having an advantage over conventional methods. Adequate controlled plasma drug levels, reduced side effects as well as improved patient compliance are some of the benefits that these systems may offer. Controlled delivery systems that can provide zero-order drug delivery have the potential for maximizing efficacy while minimizing dose frequency and toxicity. Thus, zero-order drug release is ideal in a large area of drug delivery which has therefore led to the development of various technologies with such drug release patterns. Systems such as multilayered tablets and other geometrically altered devices have been created to perform this function. One of the principles of multilayered tablets involves creating a constant surface area for release. Polymeric materials play an important role in the functioning of these systems. Technologies developed to date include among others: Geomatrix® multilayered tablets, which utilizes specific polymers that may act as barriers to control drug release; Procise®, which has a core with an aperture that can be modified to achieve various types of drug release; core-in-cup tablets, where the core matrix is coated on one surface while the circumference forms a cup around it; donut-shaped devices, which possess a centrally-placed aperture hole and Dome Matrix® as well as “release modules assemblage”, which can offer alternating drug release patterns. This review discusses the novel altered geometric system technologies that have been developed to provide controlled drug release, also focusing on polymers that have been employed in such developments.
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影响因子：
3.4
作者：
Deshpande, AA;Rhodes, CT;Malick, AW
通讯作者：
Malick, AW
影响因子：
3.8
作者：
BROOKE, D;WASHKUHN, RJ
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WASHKUHN, RJ
影响因子：
5.8
作者：
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影响因子：
5.8
作者：
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通讯作者：
DANCKWERTS, MP
影响因子：
2.8
作者：
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通讯作者：
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