Impact of laparoscopic liver resection on liver regeneration
Impact of laparoscopic liver resection on liver regeneration
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DOI：
10.1007/s00464-022-09155-4
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发表时间：
2022-03
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通讯作者：
Yasuko Matsuo;Daisuke Hokuto;Satoshi Yasuda;T. Yoshikawa;N. Kamitani;Shunsuke Doi;K. Nakagawa;S. Nishiwada;M. Nagai;T. Terai;M. Sho
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作者：
Yasuko Matsuo;Daisuke Hokuto;Satoshi Yasuda;T. Yoshikawa;N. Kamitani;Shunsuke Doi;K. Nakagawa;S. Nishiwada;M. Nagai;T. Terai;M. Sho
背景肝切除术后的肝再生在预防肝切除术后肝衰竭中发挥着重要作用。本研究旨在评估和比较腹腔镜肝切除术（LLR）和开腹肝切除术（OLR）对肝再生的影响。方法纳入2010年1月至2018年12月期间在我院因肝细胞癌、胆管细胞癌和结直肠肝转移接受根治性解剖肝切除术的患者。将患者分为OLR组和LLR组。计算术前肝脏体积（PLV）、未来残余肝脏体积、切除肝脏体积（RLV）、术后1个月肝脏体积和术后6个月肝脏体积。肝脏再生率定义为RLV的增加率，肝脏恢复率定义为PLV的返回率。结果该研究包括72名患者。其中，OLR组43人，LLR组29人。两组之间的基线特征和手术程序没有观察到差异。此外，术后1个月（OLR vs. LLR：68.9% vs. 69.0%，p= 0.875）和术后6个月（91.8% vs. 93.2%，p= 0.995）的肝脏再生率没有观察到显着差异。此外，术后1个月（90.3% vs. 90.6%，p= 0.893）和术后6个月（96.9% vs. 98.8%，p= 0.986）两组之间的肝脏恢复率没有显着差异。 结论 肝切除术后的肝脏再生不受手术类型的影响，腹腔镜和开腹手术的效果相似。 再生率和恢复率。
BackgroundLiver regeneration after liver resection plays an important role in preventing posthepatectomy liver failure. In this study, we aimed to evaluate and compare the impact of laparoscopic liver resection (LLR) and open liver resection (OLR) on liver regeneration.MethodsPatients who underwent curative anatomical liver resection for hepatocellular carcinoma, cholangiocellular carcinoma, and colorectal liver metastases at our institution between January 2010 and December 2018 were included in this study. The patients were divided into the OLR and LLR groups. Preoperative liver volume (PLV), future remnant liver volume, resected liver volume (RLV), liver volume at 1 month after the surgery, and liver volume at 6 months after the surgery were calculated. The liver regeneration rate was defined as the increase in the rate of RLV, and the liver recovery rate was defined as the rate of return to the PLV.ResultsThe study included 72 patients. Among them, 43 were included in the OLR group and 29 were included in the LLR group. No differences were observed in the baseline characteristics and surgical procedures between the two groups. Moreover, no significant difference was observed in the liver regeneration rate at 1 month after the surgery (OLR vs. LLR: 68.9% vs. 69.0%,p= 0.875) and at 6 months after the surgery (91.8% vs. 93.2%,p= 0.995). Furthermore, the liver recovery rates were not significantly different between the two groups at 1 month after the surgery (90.3% vs. 90.6%,p= 0.893) and at 6 months after the surgery (96.9% vs. 98.8%,p= 0.986).ConclusionLiver regeneration after liver resection is not affected by the type of surgical procedure and both laparoscopic and open procedures yield similar regeneration and recovery rates.