Role of complement in diabetes
Role of complement in diabetes
复制标题
DOI：
10.1016/j.molimm.2019.07.031
复制
发表时间：
2019-10-01
影响因子：
3.6
通讯作者：
Schroeder, Verena
中科院分区：
文献类型：
--
作者：
Ajjan, Ramzi A.;Schroeder, Verena
越来越多的证据表明，补体系统在糖尿病的发病机制和导致这种疾病的血管并发症中起作用。补体蛋白通过增强潜在的器官特异性自身免疫过程而促进1型糖尿病（T1 D）的发展。补体上调和激活也是胰岛素抵抗和2型糖尿病（T2 D）发展的重要特征。此外，动物和人类研究表明，补体蛋白参与导致糖尿病微血管和大血管并发症的致病机制。补体的不良血管效应似乎与炎症过程的增强和血栓形成环境的易感性有关，最终导致血管闭塞。补体蛋白被认为是预防或治疗血管疾病的治疗靶点，但研究主要在动物模型中进行，而人类的工作迄今为止既有限又不确定。需要进一步研究以了解补体蛋白作为治疗靶点的潜在作用，用于逆转导致T1 D和T2 D的病理过程以及预防/治疗糖尿病血管并发症。
Accumulating evidence suggests a role for the complement system in the pathogenesis of diabetes and the vascular complications that characterise this condition. Complement proteins contribute to the development of type 1 diabetes (T1D) by enhancing the underlying organ-specific autoimmune processes. Complement upregulation and activation is also an important feature of insulin resistance and the development of type 2 diabetes (T2D). Moreover, animal and human studies indicate that complement proteins are involved in the pathogenic mechanisms leading to diabetic microvascular and macrovascular complications. The adverse vascular effects of complement appear to be related to enhancement of the inflammatory process and the predisposition to a thrombotic environment, eventually leading to vascular occlusion. Complement proteins have been considered as therapeutic targets to prevent or treat vascular disease but studies have been mainly conducted in animal models, while human work has been both limited and inconclusive so far. Further studies are needed to understand the potential role of complement proteins as therapeutic targets for reversal of the pathological processes leading to T1D and T2D and for the prevention/treatment of diabetic vascular complications.