Preventive effects of low molecular weight heparin on formation of deep vein thrombosis by reducing D dimer values in patients undergoing spinal surgery
Preventive effects of low molecular weight heparin on formation of deep vein thrombosis by reducing D dimer values in patients undergoing spinal surgery
复制标题
低分子肝素降低脊柱手术患者D二聚体值对深静脉血栓形成的预防作用
DOI：
10.26355/eurrev_201801_14122
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Zhao, J. -H.
中科院分区：
文献类型：
--
作者：
Yin, X.;Liu, P.;Zhao, J. -H.
目的：深静脉血栓形成（DVT）是脊柱手术患者最常见的并发症之一。本研究旨在探讨低分子量肝素（LMWH）对DVT形成的预防作用。患者和方法：本研究涉及37例在2016年4月至2017年4月期间接受脊柱手术的患者。将患者分为LMWH组和对照组。记录手术时间、术中出血量、切口长度、术后视觉模拟评分（VAS）、下床活动时间、术后拔管时间等临床参数。还进行了血常规分析，包括血小板计数（PLT）、红细胞计数（RBC）、白色细胞计数（WBC）和血红蛋白（HGB）。检测凝血指标包括凝血酶原时间-国际标准化比值（PT-INR）、纤维蛋白原（FIB）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、凝血酶原时间1（PT-1）和D-二聚体（DD）。结果：LMWH组术后第1、3、7天手术时间、术中出血量及切口长度均较对照组明显缩短（均P
OBJECTIVE: Deep vein thrombosis (DVT) is one of the most common complications for patients undergoing spinal surgery. This study aims to investigate preventive effects of low-molecular-weight heparin (LMWH) on the formation of DVT.PATIENTS AND METHODS: This study involved 37 patients who underwent spinal surgery between April 2016 and April 2017. Patients were divided into LMWH group and Control group. Clinical parameters, including operation time, intra-operative blood loss, incision length, post-operative visual analogue scale (VAS), exercise-time leaving bed and post-operative extubation time, were collected. Blood routine analysis, including platelet count (PLT), red blood cell count (RBC), white blood cell count (WBC) and hemoglobin (HGB) were also conducted. Coagulation parameters, including prothrombin time-international normalized ratio (PT-INR), fibrinogen (FIB), activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time 1 (PT-1) and D-dimer (DD), were evaluated. The drainage fluid was collected.RESULTS: LMWH treatment significantly decreased operative time, blood loss and incision length compared to Control group at 1st, 3rd and 7th day post-operation (all p