HA-RAS AUGMENTS C-JUN ACTIVITY AND STIMULATES PHOSPHORYLATION OF ITS ACTIVATION DOMAIN
HA-RAS AUGMENTS C-JUN ACTIVITY AND STIMULATES PHOSPHORYLATION OF ITS ACTIVATION DOMAIN
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DOI：
10.1038/351122a0
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发表时间：
1991-05-09
期刊：
影响因子：
64.8
通讯作者：
KARIN, M
中科院分区：
文献类型：
--
作者：
BINETRUY, B;SMEAL, T;KARIN, M
Ha-Ras通过增强c-Jun激活结构域的活性来增强c-Jun介导的反式激活。Ha-Ras还导致c-Jun蛋白质的该部分中特定位点的磷酸化相应增加。Ha-Ras诱导的蛋白激酶级联反应导致c-Jun激活结构域过度磷酸化，这可以解释这些癌蛋白如何合作转化大鼠胚胎成纤维细胞。
Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts.