Evaluation of human immunodeficiency virus (HIV) type 1 load, CD4 T cell level, and clinical class as time-fixed and time-varying markers of disease progression in HIV-1-infected children.
Evaluation of human immunodeficiency virus (HIV) type 1 load, CD4 T cell level, and clinical class as time-fixed and time-varying markers of disease progression in HIV-1-infected children.
复制标题
评估人类免疫缺陷病毒 (HIV) 1 型载量、CD4 T 细胞水平和临床分类作为 HIV-1 感染儿童疾病进展的时间固定和时变标记。
DOI：
10.1086/315064
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Lew,JF
中科院分区：
文献类型：
--
作者：
Kalish,LA;McIntosh,K;Read,JS;Diaz,C;Landesman,SH;Pitt,J;Rich,KC;Shearer,WT;Davenny,K;Lew,JF
Human immunodeficiency virus (HIV) type 1 RNA load, CD4 T cell level, and Centers for Disease Control and Prevention (CDC) clinical class history were measured as potential correlates of a CDC class C diagnosis or death in 165 HIV-1—infected children followed from birth. These covariates were assessed at fixed “landmark” ages from 6 to 24 months and were also assessed as time-varying values. Virus load was associated with progression in all analyses, even after adjusting for immunologic and clinical status. This confirms its importance for monitoring pediatric disease progression. CD4 T cell level was associated with disease progression in time-varying but not in adjusted landmark analysis, suggesting that CD4 cells reflects immediate risk more than long-term risk. The distinction between clinical class B and lower classes is prognostic during the first 18 months of life; class C versus classes N/A/B becomes more important as the patient ages. Virologic, immunologic, and clinical status all provide information regarding disease progression risk.
