Neutrophil to Lymphocyte Ratio as a Novel Predictor of Outcome in Patients With Severe Traumatic Brain Injury
Neutrophil to Lymphocyte Ratio as a Novel Predictor of Outcome in Patients With Severe Traumatic Brain Injury
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DOI：
10.1097/htr.0000000000000320
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发表时间：
2018-01-01
影响因子：
2.4
通讯作者：
Wang, Shousen
中科院分区：
文献类型：
--
作者：
Chen, Weiqiang;Yang, Jinhua;Wang, Shousen
目的：中性粒细胞与淋巴细胞比值（NLR）是危重病预后的预测指标。目的探讨重型颅脑损伤（TBI）患者NLR的变化及其与预后的关系。背景：中国。研究对象：2007年1月至2012年4月，共855例重度TBI患者。设计：回顾性。主要衡量标准：收集了关于国家生命力和其他指标的数据。随访至死亡或1年后，回顾性分析NLR与TBI结局之间的关系。结果：最终分析包括688例患者。头部创伤后1年，有508人（73.8%）的结局不利。预后不良组入院时的NLR值显著高于预后良好组（P <0.001）。多变量logistic分析显示，较高的NLR与不良结局相关（比值比，1.100; P <.001）。受试者工作特征曲线分析显示，以最佳阈值为基础，NLR预测1年不良结局的敏感性为60.2%，特异性为71.1%。结论：NLR可能是一个新的预测严重TBI患者1年预后和死亡率的指标。
Objective: The neutrophil to lymphocyte ratio (NLR) has been reported to be a predictor of outcome in critical illness. Objective of this study was to investigate the changes of the NLR in patients with severe traumatic brain injury (TBI) and analyze the relationship between the NLR and TBI outcome. Setting: China. Participants: A total of 855 patients with severe TBI from January 2007 to April 2012. Design: Retrospective. Main Measurement: Data on the NLR and other indicators were collected. After follow-up until death or 1 year, the relationship between the NLR and TBI outcome was analyzed retrospectively. Results: The final analysis included 688 patients. There were 508 (73.8%) who had an unfavorable outcome by 1 year after head trauma. The value of the NLR on admission was significantly higher in the unfavorable outcome group than in the favorable outcome group (P < .001). Multivariate logistic analysis showed that higher NLR was associated with an unfavorable outcome (odds ratio, 1.100; P < .001). Receiver operating characteristic curve analysis showed that the NLR had a sensitivity of 60.2% and a specificity of 71.1% for predicting unfavorable outcome at 1 year on the basis of the best threshold. Conclusion: The NLR might be useful as a novel predictor for 1-year outcome and mortality in severe TBI.