Epidemiology of the non-Hodgkin's lymphomas: Distributions of the major subtypes differ by geographic locations
Epidemiology of the non-Hodgkin's lymphomas: Distributions of the major subtypes differ by geographic locations
复制标题
DOI：
10.1023/a:1008265532487
复制
发表时间：
1998-07-01
影响因子：
50.5
通讯作者：
Weisenburger, DD
中科院分区：
文献类型：
--
作者：
Anderson, JR;Armitage, JO;Weisenburger, DD
背景资料：有没有以前的系统性研究的分布的主要亚型的非霍奇金淋巴瘤（NHL）的地理区域，虽然已经有孤立的报告，这种差异设计：作为临床评价的一部分，国际淋巴瘤研究组（ILSG）分类的NHL，我们分类1378 NHL从8个不同的地理位置（Omaha，NE，USA;温哥华，BC，Canada; Capetown，South Africa;伦敦，England; Wurzburg/Gottingen，德国;里昂，France;洛迦诺/贝林佐纳，瑞士; and Hong Kong）使用ILSG分类。在北美、伦敦和开普敦观察到滤泡性淋巴瘤的百分比更高（31%对其他地点的14%）。外周T细胞淋巴瘤多见于伦敦。开普敦和香港（9%）比其他地方（3%）。在洛迦诺/贝林佐纳，纵隔大B细胞淋巴瘤（9%比2%）和套细胞淋巴瘤（14%比6%）的比例较高。血管中心性鼻T/NK细胞淋巴瘤仅见于香港（8%）和里昂（2%）。这些结果表明，地理差异的病因或宿主因素可能是负责观察到的差异，在NHL亚型的病例分布。
Background: There has been no previous systematic study of the distribution of the major subtypes of non-Hodgkin's lymphoma (NHL) across geographic regions, although there have been isolated reports of such differences.Design: As part of a clinical evaluation of the International Lymphoma Study Group (ILSG) classification of NHL, we classified 1378 NHLs from eight different geographic sites (Omaha, NE, USA; Vancouver, BC, Canada; Capetown, South Africa; London, England; Wurzburg/Gottingen, Germany; Lyon, France; Locarno/Bellinzona, Switzerland; and Hong Kong) using the ILSG classification.Results: Substantial differences were found in the distribution of the major subtypes of NHL across geographic regions (P < 0.0001). A greater percentage of follicular lymphoma was seen in North America, London and Capetown (31% versus 14% at other sites). Peripheral T-cell lymphoma was more common in London. Capetown and Hong Kong (9%) than elsewhere (3%). In Locarno/Bellinzona, higher percentages of mediastinal large B-cell lymphoma (9% versus 2% elsewhere) and mantle cell lymphoma (14% versus 6% elsewhere) were seen. Angiocentric nasal T-/NK-cell lymphoma was only seen in Hong Kong (8%) and Lyon (2%).Conclusions: Our study provides evidence that the distribution of NHL subtypes differs by geographic region. These findings suggest that geographical differences in etiologic or host factors may be responsible for the observed differences in the distribution of cases across NHL subtypes.