Reactive oxygen species: Destroyers or messengers?
Reactive oxygen species: Destroyers or messengers?
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DOI：
10.1016/j.bcp.2008.11.009
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发表时间：
2009-04-15
影响因子：
5.8
通讯作者：
Bartosz, Grzegorz
中科院分区：
文献类型：
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作者：
Bartosz, Grzegorz
大量证据表明，活性氧（ROS）不仅是氧代谢不可避免的副产物，而且在细胞信号传导中发挥作用。ROS由NADPH氧化酶家族产生，用于信号传导目的，并介导或增强胰岛素、生长因子、细胞因子和G蛋白偶联受体的作用。ROS信号传导的干扰导致这些中间体的过度产生，在各种疾病的过程中造成细胞组分的氧化损伤。因此，恢复适当的ROS信号传导，特别是抑制ROS的细胞来源，可能提供新的治疗方法。(C)2008年爱思唯尔公司All rights reserved.
Abundant evidence leaves no doubt that reactive oxygen species (ROS) are not only inevitable by-products of oxygen metabolism but also play a role in cellular signaling. ROS are produced by a family of NADPH oxidases for signaling purposes and mediate or augment the effects of insulin, growth factors, cytokines and G-protein-coupled receptors. Disturbances of ROS signaling leading to overproduction of these intermediates inflict oxidative damage of cell components in the course of various diseases. Restoration of proper ROS signaling, especially inhibition of cellular sources of ROS, may thus provide new ways of therapy. (C) 2008 Elsevier Inc. All rights reserved.