Plantar reflex excitability is increased in the evening in restless legs syndrome patients
Plantar reflex excitability is increased in the evening in restless legs syndrome patients
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DOI：
10.1016/j.neulet.2017.09.027
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发表时间：
2017-11-01
影响因子：
2.5
通讯作者：
Kerr, Samantha
中科院分区：
文献类型：
--
作者：
Dafkin, Chloe;Green, Andrew;Kerr, Samantha
目的：研究不宁腿综合征（restless legs syndrome，RLS）患者与健康对照组（healthmatchedcontrols.Methods）相比，脊髓兴奋性（足底反射）是否发生昼夜变化。足底反射反应进行了评估肌电图，使用运动分析（运动学）和主观伤害感受（视觉Anesthesia Scale）。结果：RLS参与者表现出昼夜节律的变化，足底反射反应，而对照组参与者没有。RLS参与者的夜间踝关节角度变化比早晨反应更大，更快。此外，RLS参与者显示出显着较小的变化，踝关节的角度和显着较慢的踝关节运动在晚上和早上，以及显着较低的腓肠肌外侧最大振幅相比，对照participator.Conclusion：目前的研究结果支持的理论RLS的昼夜节律波动的脊髓兴奋性。一个意想不到的发现是与健康对照参与者相比，RLS参与者的足底反射反应降低。然而，这一发现支持RLS中机械性感觉减退的理论。这项研究的结果进一步深入了解RLS的病理生理学，强调并非所有的感觉处理都以相同的方式受到影响。
Objective: To investigate if diurnal changes in spinal excitability (plantar reflex) occur in restless legs syndrome (RLS) participants compared to healthy matched controls.Methods: Thirteen RLS participants and 13 healthy control participants' plantar reflex responses were evaluated in the evening (PM) and the morning (AM). Plantar reflex responses were assessed electromyographically, using motion analysis (kinematically) and by subjective nociception (Visual Analogue Scale).Results: RLS participants showed a circadian variation in plantar reflex responses whilst control participants did not. Evening ankle angle changes were larger and faster in RLS participants compared to morning responses. In addition RLS participants displayed significantly smaller change in ankle angle and significantly slower ankle movements in the evening and the morning as well as significantly lower lateral gastrocnemius maximum amplitude in the compared to control participants.Conclusion: The findings of the current study support the theory of RLS circadian fluctuations in spinal excitability. An unexpected finding was decreased plantar reflex responses in RLS participants compared to healthy control participants. However this finding supports the theory of mechanical hypoesthesia in RLS. The results of this study provide further insight into the pathophysiology of RLS, highlighting that not all sensory processing is affected in the same manner.