Heparanase and its related molecules in odontogenic tumors
Heparanase and its related molecules in odontogenic tumors
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DOI：
10.3353/omp.13.81
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
H. Nagatsuka;Katase Naoki;Han Phuu Pwint;H. Tsujigiwa;S. Huat;M. Nakajima;Y. Naomoto;R. Tamamura;T. Kawakami;G. Mehmet
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文献类型：
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作者：
H. Nagatsuka;Katase Naoki;Han Phuu Pwint;H. Tsujigiwa;S. Huat;M. Nakajima;Y. Naomoto;R. Tamamura;T. Kawakami;G. Mehmet
硫酸乙酰肝素蛋白多糖(HSPGs)是一类广泛存在于细胞表面和细胞外基质(ECM)中的大分子。HSPG的HS链可以结合多种分子，包括生长因子、细胞因子和趋化因子。因此，内切糖苷酶对HS链的降解将对细胞功能产生深远影响。乙酰肝素酶是一种哺乳动物内切β-葡萄糖醛酸苷酶，能选择性降解HS链。除酶功能外，乙酰肝素酶在人类肿瘤中优先表达，其在肿瘤细胞中的过度表达提供了侵袭性表型。我们以前报道过乙酰肝素酶的表达和HS结合的分子在牙源性肿瘤的发生和发展中起重要作用。结论：牙源性肿瘤的生长和发展与HS和肝素酶分子的免疫表达和定位紊乱有关，肝素酶可能通过调节HS结合生长因子的可获得性和功能而参与牙源性肿瘤的生长和发展。
Heparan sulphate proteoglycans (HSPGs) constitute a group of ubiquitous macromolecules of cell surface and extracellular matrices (ECM). HS chains of HSPGs can bind numerous molecules including growth factors, cytokines and chemokines. Thus the degradation of HS chains by endoglycosidases will affect profoundly cell function. Heparanase is a mammalian endo-β-glucuronidase enzyme capable of selectively degrading HS chains. Aside from the enzymatic functions, heparanase is preferentially expressed by human tumors, and its over-expression in tumor cells provides invasive phenotype. We previously reported that heparanase expression and the HS-bound molecules are important for odontogenesis and development of odontogenic tumors. It can be concluded that the growth and progression of benign and malignant odontogenic tumors are related to the deranged immunoexpression and localization of HS and heparanase molecules and that heparanase may be responsible for growth and progression of odontogenic tumors by modulating the availability and function of HS binding growth factors.