Iron metabolism and the exocrine pancreas
Iron metabolism and the exocrine pancreas
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DOI：
10.1016/j.cca.2020.10.013
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发表时间：
2020-12-01
影响因子：
5
通讯作者：
Petrov, Maxim S.
中科院分区：
文献类型：
--
作者：
Kimita, Wandia;Petrov, Maxim S.
虽然铁代谢严重紊乱的病理生理机制和后果已为人所知，但对铁代谢轻到中度改变的病理生理机制及其后果却知之甚少。越来越多的证据表明，胰腺外分泌与铁代谢存在双向关系。研究表明，胰腺炎患者铁代谢、铁吸收和胰腺内铁沉积的循环标志物发生了变化。与此同时，胰腺外分泌功能障碍已在铁超载障碍中表现出来。这些观察揭示了胰腺外分泌和铁代谢之间的令人信服的联系，通过观察铁络合剂和胰酶替代疗法的治疗效果进一步阐明了这一点。虽然胰腺不是体内铁的主要储存库，但更好地了解它与铁代谢的关系可能会产生意想不到的见解。
Although the pathophysiological mechanisms and consequences of gross derangements in iron metabolism are well known, little is known about the pathophysiological mechanisms underlying mild-to-moderate alterations in iron metabolism and their consequences. Growing evidence indicates that the exocrine pancreas has a bidirectional relationship with iron metabolism. Studies have shown alterations in circulating markers of iron metabolism, iron absorption, and intra-pancreatic iron deposition in pancreatitis. At the same time, exocrine pancreatic dysfunction has been shown in iron overload disorders. These observations reveal a compelling connection between the exocrine pancreas and iron metabolism, which are further elucidated by observations of therapeutic benefits of iron chelating agents and pancreatic enzyme replacement therapy. While the pancreas is not a major reservoir of iron in the body, better understanding of its relationship with iron metabolism may yield unexpected insights.