The epidemiology of left ventricular hypertrophy in type 2 diabetes mellitus
The epidemiology of left ventricular hypertrophy in type 2 diabetes mellitus
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DOI：
10.1007/s00125-005-1896-y
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发表时间：
2005-10-01
期刊：
影响因子：
8.2
通讯作者：
Struthers, AD
中科院分区：
文献类型：
--
作者：
Dawson, A;Morris, AD;Struthers, AD
目的/假设：2型糖尿病患者比一般人群有更大的心血管风险。虽然人们普遍认为糖尿病是冠状动脉疾病的一个危险因素，但在这一人群中，潜在致命性左心室异常的患病率增加却鲜为人知。方法：对500例2型糖尿病患者进行超声心动图研究，评估左室肥厚（LVH）和左室收缩功能障碍（LVSD）的患病率。我们还评估了是否存在舒张充盈参数异常。结果：在371例左心室质量可以成功评估的患者中，264例LVH（71%）。左心室收缩功能不全则少见，为16/385（4.2%）。429例患者中有29例（6.8%）长轴收缩异常。舒张充盈异常在178/435（41%）的患者中存在，这些患者可以根据所选择的标准进行分类。结论：左心室异常在2型糖尿病患者中很常见。由于药物治疗可用于LVH和LVSD，并且已被证明可减少心血管死亡，因此这些左心室异常可能是筛查的理想目标，然后进行选择性治疗干预。
Aims/hypothesis: Patients with type 2 diabetes mellitus are at greater cardiovascular risk than the general population. Although it is widely acknowledged that diabetes is a risk factor for coronary artery disease, the increased prevalence of potentially lethal left ventricular abnormalities in this population is less well appreciated. Methods: We carried out an echocardiographic study of 500 subjects with type 2 diabetes mellitus to assess the prevalence of left ventricular hypertrophy (LVH) and left ventricular systolic dysfunction (LVSD). We also assessed whether abnormalities in diastolic filling parameters were present. Results: Of the 371 patients in whom left ventricular mass could be successfully assessed, 264 had LVH (71%). Left ventricular systolic dysfunction was much less common, being present in 16/385 patients (4.2%). Long axis contraction was abnormal in 29/429 patients (6.8%). Diastolic filling abnormalities were present in 178/435 (41%) of patients who could be classified using the selected criteria. Conclusions: We conclude that left ventricular abnormalities are common in type 2 diabetic patients. As medical therapy is available for both LVH and LVSD and has been demonstrated to reduce cardiovascular death, these left ventricular abnormalities could be ideal targets for screening, followed by selective therapeutic intervention.