High density lipoprotein-cholesterol levels increase with age in American women but not in Hong Kong Chinese women
High density lipoprotein-cholesterol levels increase with age in American women but not in Hong Kong Chinese women
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DOI：
10.1111/j.1365-2265.2008.03361.x
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发表时间：
2009-04-01
影响因子：
3.2
通讯作者：
Lam, Karen S. L.
中科院分区：
文献类型：
--
作者：
Cheung, Bernard M. Y.;Li, Mingfang;Lam, Karen S. L.
高密度脂蛋白（HDL）胆固醇是一个强大的心血管危险因素。血浆HDL水平存在重要的性别和种族差异，值得调查。两种不同人群的横断面调查。1999-2002年全国健康与营养调查（NHANES）的7700名参与者和2000-2004年香港心血管危险因素流行研究2 （CRISPS2）的1944名参与者。血浆HDL水平。在这两个人群中，女性的血浆高密度脂蛋白水平都高于男性。在美国女性中，它随着年龄的增长而增加，而在中国女性中，它随着年龄的增长而下降，并与男性高密度脂蛋白水平趋同。在美国，有37.1 +/- 1.2%的男性和38.9 +/- 1.1%的女性高密度脂蛋白水平较低。在香港，34.3 +/- 1.6%的男性和34.5 +/- 1.5%的女性的高密度脂蛋白水平较低。在美国，低HDL水平的独立预测因子是年龄较小，男性是非墨西哥裔西班牙人、腰围、甘油三酯和不饮酒；年龄较小，女性是非墨西哥裔西班牙人、腰围、甘油三酯、吸烟和不饮酒。在香港华人中，高密度脂蛋白水平低的独立预测因子为男性的体重指数、甘油三酯、目前吸烟和不饮酒，女性的年龄较小、腰围、甘油三酯、糖尿病和曾经吸烟。中国女性血浆高密度脂蛋白随年龄的下降与美国女性相反。中国老年妇女心血管风险的增加需要进一步研究。
High-density lipoprotein (HDL) cholesterol is a powerful cardiovascular risk factor. Important gender and ethnic differences in plasma HDL levels exist and warrant investigation.Cross-sectional survey in two different general populations.7700 participants of the National Health and Nutrition Examination Survey (NHANES) 1999-2002 and 1944 participants of the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2) 2000-2004.Plasma HDL levels.Plasma HDL levels were higher in women than in men in both populations. In the United States women, it increased with age, whereas in Chinese women, it declined with age and converged with male HDL levels. In the United States, 37.1 +/- 1.2% men and 38.9 +/- 1.1% women had low HDL levels. In Hong Kong, 34.3 +/- 1.6% men and 34.5 +/- 1.5% women had low HDL levels. In Americans, the independent predictors of low HDL levels were lower age, being non-Mexican Hispanic, waist circumference, triglycerides and not drinking alcohol in men, and lower age, being Hispanic, waist circumference, triglycerides, current smoking and not drinking alcohol in women. In Hong Kong Chinese, the independent predictors of low HDL levels were body mass index, triglycerides, current smoking and not drinking alcohol in men, and lower age, waist circumference, triglycerides, diabetes and former smoking in women.The decline in plasma HDL with age in Chinese women is opposite to that seen in American women. The increased cardiovascular risk in elderly Chinese women requires further study.