Ubiquitin and proteasome gene expression is increased in skeletal muscle of slim AIDS patients.
Ubiquitin and proteasome gene expression is increased in skeletal muscle of slim AIDS patients.
复制标题
苗条艾滋病患者骨骼肌中泛素和蛋白酶体基因表达增加。
DOI：
10.3892/ijmm.2.1.69
复制
发表时间：
1998
影响因子：
5.4
通讯作者：
J. M. Argiles
中科院分区：
文献类型：
--
作者：
M. Llovera;C. Garcı́a;N. Agell;F. López‐Soriano;F. Authier;R. Gherardi;J. M. Argiles
从恶病质艾滋病患者骨骼肌获得的人类活组织检查清楚地显示，编码泛素-ATP依赖的蛋白分解系统的基因表达(相对于健康受试者)增加。2.4kb和1.2kb的泛素转录本分别增加了120%和42%。恶病质艾滋病患者C8蛋白酶体亚基的表达也较健康对照组增加60%。有人认为，这种蛋白分解系统的激活(可能通过循环细胞因子的变化，如肿瘤坏死因子)可能是经常伴随艾滋病而来的骨骼肌浪费的原因。
Human biopsies obtained from skeletal muscle of cachectic AIDS patients clearly showed an increased expression (in relation to that of healthy subjects) of the genes encoding for the ubiquitin-ATP-dependent proteolytic system. Increases of 120% and 42% were observed for the 2.4 and 1.2 kb ubiquitin transcripts, respectively. The expression of the C8 proteasome subunit was also increased by 60% in the cachectic AIDS patients in relation to the healthy control subjects. It is suggested that the activation of this proteolytic system (possibly via changes in circulating cytokines, such as TNF) may be responsible for the skeletal muscle waste that often accompanies AIDS.