Hedgehog signalling in vascular development
Hedgehog signalling in vascular development
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DOI：
10.1007/s10456-008-9105-5
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发表时间：
2008-03-01
期刊：
影响因子：
9.8
通讯作者：
Fujita, Toshiro
中科院分区：
文献类型：
--
作者：
Nagase, Takashi;Nagase, Miki;Fujita, Toshiro
Hedgehog蛋白家族是介导胚胎发育以及成体形态发生和癌发生的强有力的形态发生素。例如，过度的hedgehog活性与基底细胞癌、髓母细胞瘤和横纹肌肉瘤有关。最近，hedgehog信号传导与血管生成有关。虽然成年血管生成中的Hedgehog信号传导可能构成胚胎发育中的Hedgehog信号传导的简单重演，但应当理解，Hedgehog信号传导在不同发育背景下发生在胚胎血管生成中。本文综述了刺猬信号在胚胎和出生后血管发育中的作用。刺猬依赖血管生成的窗口在发展过程中的时间的重要性，强调和说明使用整个小鼠胚胎培养系统。
The Hedgehog family of proteins are powerful morphogens mediating embryonic development as well as adult morphogenesis and carcinogenesis. For example, excess hedgehog activity has been implicated in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma. More recently, hedgehog signalling has been implicated in angiogenesis. While hedgehog signalling in adult angiogenesis may constitute a simple recapitulation of that in embryonic development, it should be appreciated that Hedgehog signalling occurs in embryonic angiogenesis in different developmental contexts. This article reviews the role of Hedgehog signalling in both embryonic and postnatal vascular development. The temporal importance of a window of hedgehog dependent angiogenesis during development is emphasised and illustrated using a whole mouse embryo culture system.