Anatomically-constrained tractography: Improved diffusion MRI streamlines tractography through effective use of anatomical information
Anatomically-constrained tractography: Improved diffusion MRI streamlines tractography through effective use of anatomical information
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DOI：
10.1016/j.neuroimage.2012.06.005
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发表时间：
2012-09-01
期刊：
影响因子：
5.7
通讯作者：
Connelly, Alan
中科院分区：
文献类型：
--
作者：
Smith, Robert E.;Tournier, Jacques-Donald;Connelly, Alan
扩散 MRI 流线型纤维束成像技术存在许多固有的局限性，其中之一是准确确定何时应终止流线型。使用来自解剖图像分割的精确流线传播掩模将流线限制在大脑白质的体积内，但没有充分利用此类图像中可用的所有信息。我们提出了流线束成像的模块化补充，它可以更有效地利用从解剖图像分割中获得的信息以及正在重建的神经元轴突的已知属性，将生物学上真实的先验应用于生成的流线；我们将此称为“解剖学约束纤维束成像”。结果表明，如果使用最先进的流线纤维束成像方法，则可以防止与纤维束成像算法相关的一些已知误报，从而提高重建的生物学准确性。 (c) 2012 Elsevier Inc. 保留所有权利。
Diffusion MRI streamlines tractography suffers from a number of inherent limitations, one of which is the accurate determination of when streamlines should be terminated. Use of an accurate streamlines propagation mask from segmentation of an anatomical image confines the streamlines to the volume of the brain white matter, but does not take full advantage of all of the information available from such an image. We present a modular addition to streamlines tractography, which makes more effective use of the information available from anatomical image segmentation, and the known properties of the neuronal axons being reconstructed, to apply biologically realistic priors to the streamlines generated; we refer to this as "Anatomically-Constrained Tractography". Results indicate that some of the known false positives associated with tractography algorithms are prevented, such that the biological accuracy of the reconstructions should be improved, provided that state-of-the-art streamlines tractography methods are used. (c) 2012 Elsevier Inc. All rights reserved.