Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses
Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses
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DOI：
10.1128/jvi.02184-09
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发表时间：
2010-03-01
影响因子：
5.4
通讯作者：
Crowe, James E., Jr.
中科院分区：
文献类型：
--
作者：
Krause, Jens C.;Tumpey, Terrence M.;Crowe, James E., Jr.
2009年甲型H1N1大流行性流感病毒与1918年大流行性流感病毒在血凝素蛋白序列上具有同源性。我们发现人单克隆抗体能识别1918年和2009年血凝素头部结构域上的Sa抗原位点，该位点由于免疫选择而具有高度可变性。这些抗体在体外对2009年病毒表现出高效力，并且其中一种在体内具有显著的治疗效果。
The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.