Parity and the risk of incident dementia: a COSMIC study.
Parity and the risk of incident dementia: a COSMIC study.
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奇偶校验和出现痴呆症的风险：一项宇宙研究。
DOI：
10.1017/s2045796020000876
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发表时间：
2020-10-20
影响因子：
8.1
通讯作者：
for Cohort Studies of Memory in an International Consortium (COSMIC)
中科院分区：
文献类型：
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作者：
Bae JB;Lipnicki DM;Han JW;Sachdev PS;Kim TH;Kwak KP;Kim BJ;Kim SG;Kim JL;Moon SW;Park JH;Ryu SH;Youn JC;Lee DY;Lee DW;Lee SB;Lee JJ;Jhoo JH;Skoog I;Najar J;Sterner TR;Scarmeas N;Yannakoulia M;Dardiotis E;Riedel-Heller S;Roehr S;Pabst A;Ding D;Zhao Q;Liang X;Lobo A;De-la-Cámara C;Lobo E;Kim KW;for Cohort Studies of Memory in an International Consortium (COSMIC)
探讨产次与女性痴呆症发病风险的关系。我们汇集了来自四个欧洲国家和两个亚洲国家的六项基于人口的前瞻性队列研究的60岁或以上社区居住妇女的基线和随访数据。我们根据年龄、教育水平、高血压、糖尿病和队列调整了Cox比例风险回归模型，并按痴呆症亚型(阿尔茨海默病(AD)和非阿尔茨海默病(NAD))进行分析，调查了产次和痴呆症发生率之间的关系。在9756名基线为无痴呆症的女性中，7010人完成了一项或多项后续评估。平均随访时间为(5.4±3.1)年，550例患者出现痴呆。产次数与痴呆发病风险相关(危险比(HR)=1.07，95%可信区间(CI)=1.02~1.13)。与1-4胎(HR=1.30，95%CI=1.02-1.67)相比，多胎(5胎或更多胎)患痴呆症的风险增加30%。每胎产NAD风险增加12%(HR=1.12，95%CI=1.02~1.23)，多胎产NAD风险增加60%(HR=1.60，95%CI=1.00~2.55)，但AD风险与胎次无关。多胎妊娠是女性患痴呆症的一个重要风险因素。这可能对生育率和多胎现象普遍较高的低收入和中等收入国家的妇女产生特别重要的影响。
To investigate the association between parity and the risk of incident dementia in women. We pooled baseline and follow-up data for community-dwelling women aged 60 or older from six population-based, prospective cohort studies from four European and two Asian countries. We investigated the association between parity and incident dementia using Cox proportional hazards regression models adjusted for age, educational level, hypertension, diabetes mellitus and cohort, with additional analysis by dementia subtype (Alzheimer dementia (AD) and non-Alzheimer dementia (NAD)). Of 9756 women dementia-free at baseline, 7010 completed one or more follow-up assessments. The mean follow-up duration was 5.4 ± 3.1 years and dementia developed in 550 participants. The number of parities was associated with the risk of incident dementia (hazard ratio (HR) = 1.07, 95% confidence interval (CI) = 1.02–1.13). Grand multiparity (five or more parities) increased the risk of dementia by 30% compared to 1–4 parities (HR = 1.30, 95% CI = 1.02–1.67). The risk of NAD increased by 12% for every parity (HR = 1.12, 95% CI = 1.02–1.23) and by 60% for grand multiparity (HR = 1.60, 95% CI = 1.00–2.55), but the risk of AD was not significantly associated with parity. Grand multiparity is a significant risk factor for dementia in women. This may have particularly important implications for women in low and middle-income countries where the fertility rate and prevalence of grand multiparity are high.