Structural and functional cortical abnormalities after upper limb amputation during childhood
Structural and functional cortical abnormalities after upper limb amputation during childhood
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DOI：
10.1097/00001756-200104170-00019
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发表时间：
2001-04-17
期刊：
影响因子：
1.7
通讯作者：
Weiller, C
中科院分区：
文献类型：
--
作者：
Hamzei, F;Liepert, J;Weiller, C
功能重组已被很好地记录在人类成年人的大脑截肢后的arm. To评估截肢对发育中的大脑的影响，我们调查了6例上肢截肢的儿童早期和右侧嗅觉障碍。经颅磁刺激表明对侧皮质去抑制和扩大的兴奋区的残端。功能磁共振成像数据证实了这些塑料的变化，也显示了同侧的功能重组。在T1加权MRI中，我们发现三名患者的对侧和同侧中央沟结构畸形，两名患者的对侧顶小叶萎缩。因此，儿童时期的手臂截肢会影响两个半球的功能组织和解剖结构。NeuroReport 12：957-962（C）2001 Lippincott威廉姆斯和威尔金斯。
Functional reorganization has been well documented in the human adult brain after amputation of the arm. To assess the effects of amputation on the developing brain, we investigated six patients with upper limb amputation in early childhood and one with right dysmelia. Transcranial magnetic stimulation indicated contralateral cortical disinhibition and enlargement of the excitable area of the stump. FMRI data corroborated these plastic changes and also showed an ipsilateral functional reorganization. In the T1-weighted MRI, we found structural deformities of the contralateral and ipsilateral central sulcus in three patients and a contralateral atrophic parietal lobule in two patients. Therefore, arm amputation in childhood affects functional organization as well as anatomical structure in both hemispheres. NeuroReport 12:957-962 (C) 2001 Lippincott Williams & Wilkins.