Inhibitors of HIV-1 transcription.
Inhibitors of HIV-1 transcription.
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HIV-1 转录抑制剂。
DOI：
10.1016/0966-842x(94)90666-1
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发表时间：
1994
影响因子：
15.9
通讯作者：
Pardee,AB
中科院分区：
文献类型：
--
作者：
Li,CJ;Dezube,BJ;Biswas,DK;Ahlers,CM;Pardee,AB
B y 1993年10月，全球尚无针对HIV的治愈药物。由于发现的病例报道数量有限，尽管美国做出了巨大努力，针对艾滋病逆转录酶的研究已经取得了逆转录酶和其他多种抑制剂的成果，许多药物的靶点达到了34万个。目前正在开发的长末端重复序列（LTR）。204 000人死亡（HIV-1中心最近已成为一个有希望的目标，其他疾病控制，亚特兰大，佐治亚州，抗病毒行动的网站。本文简要介绍了病毒复制的网站）。十年的研究总结了关于周期3性质的信息。比如说：在晚期HIV已经增加了解-这种靶点和潜在的抗LTR 1980、截短、重组的病毒复制周期表达药物。可溶性CD_4（sCD_4）是一种重要的免疫调节因子，其发病机制尚不清楚，但药物治疗仍有很大的前景。Li，BJ Dezube，DK Biswas，CM Ahlers，并且由于它可以在很大程度上抑制病毒3。三
B y October 1993, the total No curative drug against HIV has yet been Because of the limited sucnumber of reported cases found, despite enormous efforts aimed at cess of reverse-transcriptase of AIDS in the USA had reverse transcriptase and a variety of other inhibitors, many agents curreached 340000, of which targets. The long terminal repeat (LTR) of rently being developed have. 204 000 have died (Centers for HIV-1 has recently become a promising been selected to target other Disease Control, Atlanta, GA, site for antiviral action. This article briefly sites of the viral replication USA). A decade of research on summarizes information on the nature of cycle3. For example; in the late HIV has increased understand- this target and potential anti-LTR 198Os, truncated, recombiing of the viral replication cycle expression drugs. nant, soluble CD4 (sCD4) was and pathogenic mechanisms’ J, thought to hold great promise but medical therapy is still C.]. Li, BJ Dezube, DK Biswas, CM Ahlers and since it can inhibit viral atlargely palliative3. The three