A novel microRNA signature predicts vascular invasion in hepatocellular carcinoma
A novel microRNA signature predicts vascular invasion in hepatocellular carcinoma
复制标题
一种新型微小核糖核酸（miRNA）特征可预测肝细胞癌中的血管侵犯
DOI：
10.1002/jcp.28690
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发表时间：
2019-11-01
影响因子：
5.6
通讯作者：
Zhang, Lianfeng
中科院分区：
文献类型：
--
作者：
Han, Bing;Zheng, Yujia;Zhang, Lianfeng
肝细胞癌（HCC）的血管侵犯（VI）是预测生存的重要临床参数。在这项研究中，我们使用Cancer Genome Atlas数据库收集了HCC患者的microRNA （miRNA）表达数据，并确定了一个与VI相关的新的miRNA特征。首先，我们将HCC患者分为有VI和没有VI的组（VI+和VI-）。根据Kaplan-Meier分析，我们鉴定出三种mirna （miRNA-210、miRNA-10b和miRNA-9-1）与VI相关。根据1年、3年和5年的受试者工作特征曲线分析，这种3 - mirna特征对HCC患者的VI具有良好的预测能力。多变量Cox回归和分层分析表明，高危评分较高的HCC患者表现出预后较差的趋势。这种3 - mirna特征提供了准确的VI预测，可作为预测HCC患者VI的独立预后指标。
Vascular invasion (VI) in hepatocellular carcinoma (HCC) is an important clinical parameter to predict survival. In this study, we collected microRNA (miRNA) expression data from HCC patients using The Cancer Genome Atlas database and identified a novel miRNA signature associated with VI. First, we categorized HCC patients into groups with or without VI (VI+ and VI-). We identified three miRNAs (miRNA-210, miRNA-10b, and miRNA-9-1) that were associated with VI according to a Kaplan-Meier analysis. This three-miRNA signature exhibited good predictive ability for VI in patients with HCC according to a receiver operating characteristic curve analysis at 1, 3, and 5 years. Patients with HCC with a high risk score exhibited a trend toward worse outcomes as determined by multivariable Cox regression and stratified analyses. This three-miRNA signature provides an accurate prediction of VI and can be used as an independent prognostic indicator for predicting VI in HCC patients.