A prospective investigation of coffee drinking and endometrial cancer incidence
A prospective investigation of coffee drinking and endometrial cancer incidence
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DOI：
10.1002/ijc.26482
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发表时间：
2012-08-15
影响因子：
6.4
通讯作者：
Sinha, Rashmi
中科院分区：
文献类型：
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作者：
Gunter, Marc J.;Schaub, Jennifer A.;Sinha, Rashmi
喝咖啡可能与子宫内膜癌风险降低有关;然而，前瞻性数据有限。此外，尚不清楚咖啡与子宫内膜癌之间的任何关联是否因咖啡因含量而异。在226,732名年龄50 - 71岁的妇女中评估了饮用咖啡与子宫内膜癌发病率的关系，这些妇女参加了NIH-AARP饮食与健康研究，并完成了基线流行病学调查问卷。经过平均9.3年的随访，有1,486例子宫内膜癌病例的数据可用。考克斯比例风险模型被用来估计咖啡与子宫内膜癌发病率的关系。根据吸烟状况、激素治疗使用（HT）和体型进行亚组分析。喝咖啡与子宫内膜癌的发病率呈负相关（每天喝3杯咖啡与不喝咖啡的风险比[HR]= 0.64，95% CI，0.51 - 0.80; P趋势= 0.0004）。咖啡与子宫内膜癌风险的关联对于普通咖啡（HR每杯= 0.90，95% CI，0.86 - 0.95）和无咖啡因咖啡（HR每杯= 0.93，95% CI，0.87 - 0.99）的消费都是明显的。咖啡与子宫内膜癌发病率的关系因HT的使用而有显著差异（Pinteraction = 0.03），仅在HT从不使用者中有明显的相关性（HR比较每天饮用>3杯与不饮用的HR = 0.54，95%CI，0.410.72; Ptrend = 0.0005）。子宫内膜癌的发病率似乎在习惯喝咖啡的女性中降低，这种关联并不因咖啡因含量而异。
Coffee drinking may be associated with reduced risk of endometrial cancer; however, prospective data are limited. Further, it is not clear whether any association between coffee and endometrial cancer differs according to coffee caffeine content. The association of coffee drinking with incidence of endometrial cancer was evaluated among 226,732 women, aged 5071, enrolled in the NIH-AARP Diet and Health Study who completed a baseline epidemiologic questionnaire. Following a mean 9.3 years of follow-up, data were available for 1,486 incident endometrial cancer cases. Cox proportional hazards models were used to estimate associations of coffee with endometrial cancer incidence. Sub-group analyses were performed according to smoking status, hormone therapy use (HT) and body habitus. Coffee drinking was inversely related to incidence of endometrial cancer (hazard ratio [HR] comparing drinking of >3 cups/day versus no cups = 0.64, 95% CI, 0.510.80; Ptrend = 0.0004). The association of coffee with endometrial cancer risk was apparent for consumption of both regular (HR per cup = 0.90, 95% CI, 0.860.95) and decaffeinated coffee (HR per cup = 0.93, 95% CI, 0.870.99). The relation of coffee with endometrial cancer incidence varied significantly by HT use (Pinteraction = 0.03) with an association only apparent among HT-never users (HR comparing drinking >3 cups/day versus no cups = 0.54, 95% CI, 0.410.72; Ptrend = 0.0005). Endometrial cancer incidence appears to be reduced among women that habitually drink coffee, an association that does not differ according to caffeine content.