Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: Data from the European Food4Me Study
Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: Data from the European Food4Me Study
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DOI：
10.1002/mnfr.201700142
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发表时间：
2017-10-01
影响因子：
5.2
通讯作者：
Brennan, Lorraine
中科院分区：
文献类型：
--
作者：
Albani, Viviana;Celis-Morales, Carlos;Brennan, Lorraine
范围：以前的工作强调了奇数链长度的饱和脂肪酸作为乳制品摄入量的潜在标志物的潜力。本研究的目的是评估这些生物标志物的再现性和它们对乳制品insufficient.Methods和结果的变化的敏感性：脂肪酸概况和食物频率问卷（FFQs）的饮食摄入量进行了测量三次超过六个月的Food 4 Me研究。通过组内相关系数（ICC）和受试者内变异系数（WCV）探讨了再现性。使用回归分析检查对饮食变化的敏感性。C15：0血液水平随时间推移显示出高度相关性（ICC：0.62，95% CI：0.57，0.68），然而，C17：0的ICC要低得多（ICC：0.32，95% CI：0.28，0.46）。C15：0的WCV为16.6%，C17：0的WCV为14.6%。总乳制品、高脂乳制品、奶酪和黄油的摄入量变化与C15：0显著相关;高脂乳制品和奶油的摄入量变化与C17：0显著相关。结论：结果提供了C15：0水平随时间变化的可重复性和对高脂乳制品摄入量变化的敏感性的证据，其结果与公认的鱼类摄入量生物标志物（EPA+DHA）相当。
Scope: Previous work highlighted the potential of odd-chain length saturated fatty acids as potential markers of dairy intake. The aim of this study was to assess the reproducibility of these biomarkers and their sensitivity to changes in dairy intake.Methods and results: Fatty acid profiles and dietary intakes from food frequency questionnaires (FFQs) were measured three times over six months in the Food4Me Study. Reproducibility was explored through intra-class correlation coefficients (ICCs) and within-subject coefficients of variation (WCV). Sensitivity to changes in diet was examined using regression analysis. C15:0 blood levels showed high correlation over time (ICC: 0.62, 95% CI: 0.57, 0.68), however, the ICC for C17:0 was much lower (ICC: 0.32, 95% CI: 0.28, 0.46). The WCV for C15:0 was 16.6% and that for C17:0 was 14.6%. There were significant associations between changes in intakes of total dairy, high-fat dairy, cheese and butter and C15:0; and change in intakes of high-fat dairy and cream and C17:0.Conclusion: Results provide evidence of reproducibility of C15:0 levels over time and sensitivity to change in intake of high-fat dairy products with results comparable to the well-established biomarker of fish intake (EPA+DHA).