The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
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天然产物艾斯拉霉素及其三种异构体缺乏抗菌活性。
DOI：
10.1021/acs.jnatprod.6b00057
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发表时间：
2016
影响因子：
5.1
通讯作者：
Mobashery,Shahriar
中科院分区：
文献类型：
--
作者：
Wang,Huan;Hesek,Dusan;Lee,Mijoon;Lastochkin,Elena;Oliver,AllenG;Chang,Mayland;Mobashery,Shahriar
合成了从埃及地中海沿岸分离的一种海洋霉属植物的天然产物埃斯霉素的四种可能的异构体。通过1h NMR，13C NMR，高分辨率质谱和x射线晶体结构测定，明确了异构体的结构。尽管早前报道了天然产物的广谱抗菌活性，但四种异构体都没有表现出任何这种活性。
Four possible isomers of essramycin, a natural product from a marineStreptomycesspecies isolated from the Egyptian Mediterranean coast, were synthesized. The structures for the isomers were assigned unequivocally by1H NMR,13C NMR, high-resolution mass spectrometry, and X-ray crystal structure determinations. Notwithstanding the earlier report of broad-spectrum antibacterial activity for the natural product, none of the four isomers exhibited any such activity.