DNA supersandwich assemblies as artificial receptors to mediate intracellular delivery of catalase for efficient ROS scavenging
DNA supersandwich assemblies as artificial receptors to mediate intracellular delivery of catalase for efficient ROS scavenging
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DNA超级三明治组件作为人工受体介导细胞内过氧化氢酶的传递以有效清除ROS
DOI：
10.1039/c9cc00201d
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发表时间：
2019-04-14
影响因子：
4.9
通讯作者：
Wang, Kemin
中科院分区：
文献类型：
--
作者：
Chen, Qiaoshu;Zhou, Shaohong;Wang, Kemin
适体定制的DNA超三明治组件被提出作为锚定到细胞膜上的人工受体，使得过氧化氢酶递送效率提高8倍。过氧化氢酶转染导致细胞内活性氧的抑制，而细胞活力也显着提高，即使暴露于过氧化氢和脂多糖环境。
Aptamer-tailored DNA supersandwich assemblies are proposed as artificial receptors anchored onto a cell membrane, enabling catalase delivery with an 8-fold enhancement in efficiency. The catalase transfection led to inhibition of intracellular ROS, while the cell viability was also remarkably improved even when exposed to H2O2 and lipopolysaccharide environments.