Comparison of Vitrectomy with Brilliant Blue G or Indocyanine Green on Retinal Microstructure and Function of Eyes with Macular Hole
Comparison of Vitrectomy with Brilliant Blue G or Indocyanine Green on Retinal Microstructure and Function of Eyes with Macular Hole
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DOI：
10.1016/j.ophtha.2012.06.048
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发表时间：
2012-12-01
期刊：
影响因子：
13.7
通讯作者：
Yamamoto, Shuichi
中科院分区：
文献类型：
--
作者：
Baba, Takayuki;Hagiwara, Akira;Yamamoto, Shuichi
目的：评价黄斑裂孔（MH）手术后内、外视网膜的显微结构和视功能，使用亮蓝G（BBG）或吲哚菁绿色（ICG）使内界膜（ILM）更清晰。设计：比较性、回顾性、干预性病例系列。2011年1月至8月，35例35眼患者接受了BBG治疗。方法：2009年4月至2010年4月，对28例（28眼）MH患者行ICG治疗。方法：采用23 G玻璃体切割术，术中加入0.25mg/ml BBG或0.125%ICG。在光谱域光学相干断层扫描图像上测量光感受器内节/外节（IS/OS）连接和外界膜（ELM）的缺损长度、中央凹厚度（CFT）和神经节细胞复合体（GCC）的厚度。术后3个月（P = 0.021）和6个月（P = 0.045）时，BBG组的平均BCVA显著优于ICG组。BBG组的平均视网膜敏感度在3个月和6个月时在中央2处显著改善（分别为P = 0.001和P = 0.030），但在相邻10处没有显著改善。3个月时BBG组IS/OS连接缺损的长度显著较短（P = 0.048），但6个月时无显著差异（P = 0.135）。在3个月和6个月时，两组之间的ELM缺损长度和GCC厚度没有显著差异。ICG组CFT在3个月和6个月时均明显薄于BBG组（P = 0.013和P = 0.001）。结论：BBG辅助玻璃体切割术后的术后BCVA和中央2区视网膜敏感度较好。BBG组IS/OS连接恢复较快，ICG后CFT明显变薄。亮蓝G可能是一个比ICG更好的代理，使ILM更明显。财务披露（S）：作者（S）没有任何专有或商业利益，在本文中讨论的任何材料。Ophthalmology 2012;119：2609-2615（C）2012，美国眼科学会。
Purpose: To evaluate the microstructure of the inner and outer retina and the visual function after macular hole (MH) surgery using brilliant blue G (BBG) or indocyanine green (ICG) to make the internal limiting membrane (ILM) more visible.Design: Comparative, retrospective, interventional case series.Participants: Sixty-three eyes of 63 consecutive cases with MH were studied. Thirty-five eyes of 35 cases were treated with BBG between January and August 2011. Twenty-eight eyes of 28 MH cases were treated with ICG from April 2009 through April 2010.Methods: Vitrectomy was performed with a 23-gauge system and 0.25 mg/ml BBG or with 0.125% ICG.Main Outcome Measures: The best-corrected visual acuity (BCVA) and the microperimetry-determined retinal sensitivity were measured at baseline and at 3 and 6 months after surgery. The length of the defect of the photoreceptor inner segment/outer segment (IS/OS) junction and external limiting membrane (ELM), the central foveal thickness (CFT), and the thickness of the ganglion cell complex (GCC) were measured in the spectraldomain optical coherence tomographic images.Results: The average BCVA was significantly better in the BBG group than in the ICG group at 3 months (P = 0.021) and 6 months (P = 0.045) after surgery. The mean retinal sensitivity in the BBG group was improved significantly in the central 2 at 3 and 6 months (P = 0.001 and P = 0.030, respectively), but was not significantly improved in the adjacent 10. The length of IS/OS junction defect was significantly shorter in the BBG group at 3 months (P = 0.048), but was not significantly different at 6 months (P = 0.135). The length of ELM defect and the GCC thickness were not significantly different between the 2 groups at 3 and 6 months. The CFT was significantly thinner in the ICG group than in the BBG group at 3 and 6 months (P = 0.013 and P = 0.001, respectively).Conclusions: The postoperative BCVA and retinal sensitivity in the central 2 were better in eyes after BBG-assisted vitrectomy. The restoration of IS/OS junction was faster in the BBG group, and the CFT was significantly thinner in eyes after ICG. Brilliant blue G may be a better agent than ICG to make the ILM more visible.Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2012;119:2609-2615 (C) 2012 by the American Academy of Ophthalmology.