Fasting decreases triiodothyronine receptor capacity.
Fasting decreases triiodothyronine receptor capacity.
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禁食会降低三碘甲状腺原氨酸受体的能力。
DOI：
10.1126/science.204004
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发表时间：
1978
期刊：
影响因子：
56.9
通讯作者：
J. Orlando
中科院分区：
文献类型：
--
作者：
G. Schussler;J. Orlando
禁食通过减少核T3受体的结合能力降低肝细胞核与血清三碘甲状腺原氨酸（T3）的比率。结合空腹引起的血清T3浓度降低，受体含量的减少导致核T3受体复合物显著减少。禁食动物中T3受体含量和循环T3的变化似乎是禁食状态下热量保存的独立协同适应。与激素水平的变化不同，核受体含量的改变提供了一种机制，可以保护具有低热量储备的细胞，而不依赖于整个动物的代谢状态。
Fasting decreases the ratio of hepatic nuclear to serum triiodothyronine (T3) by diminishing the binding capacity of nuclear T3 receptors. In combination with the lower serum T3 concentration caused by fasting, the decrease in receptor content results in a marked decrease in nuclear T3-receptor complexes. The changes in T3 receptor content and circulating T3 in fasted animals appear to be independent synergistic adaptations for caloric conservation in the fasted state. Unlike changes in hormonal level, the modification of nuclear receptor content provides a mechanism that may protect cells with a low caloric reserve independently of the metabolic status of the whole animal.