The molecular basis of hepatitis B e antigen (HBeAg)‐negative infections
The molecular basis of hepatitis B e antigen (HBeAg)‐negative infections
复制标题
乙型肝炎e抗原（HBeAg）阴性感染的分子基础
作者：
Y. Miyakawa;H. Okamoto;M. Mayumi
乙肝e抗原(HBeAg)阴性感染是一种不寻常的慢性乙肝病毒感染形式，尽管有HBeAg抗体，病毒复制和肝脏损害仍持续存在。这种形式的乙肝病毒可能与暴发性肝炎有关。HBeAg阴性表型的分子基础已经得到了广泛的研究，最常见的是前核心区突变的结果。然而，其他突变可以引起这种表型，它们的研究和特征可能会揭示慢性病毒性肝炎的发病机制的新见解。
Hepatitis B e antigen (HBeAg)‐negative infections are an unusual form of chronic hepatitis B virus (HBV) infection in which viral replication and liver damage persist despite antibodies against HBeAg. This form of HBV may be associated with fulminant hepatitis. The molecular basis for an HBeAg‐minus phenotype has been extensively studied and is most often a result of mutations in the precore region. However, other mutations can give rise to this phenotype and their investigation and characterization may reveal new insights into the pathogenesis of chronic viral hepatitis.
DOI：
10.1073/pnas.88.23.10445
发表时间：
1991-12-01
影响因子：
11.1
作者：
BERTOLETTI, A;FERRARI, C;CHISARI, FV
通讯作者：
CHISARI, FV
影响因子：
158.5
作者：
LIANG, TJ;HASEGAWA, K;BENPORATH, E
通讯作者：
BENPORATH, E