Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes
Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes
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DOI：
10.1111/all.12626
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发表时间：
2015-07-01
期刊：
影响因子：
12.4
通讯作者：
Torrent, M.
中科院分区：
文献类型：
--
作者：
Casas, L.;Sunyer, J.;Torrent, M.
研究背景在生命早期暴露于室内过敏原可能在免疫系统的发育和哮喘的发生中起作用。目的描述在生命早期居室灰尘中屋尘螨（HDM）过敏原的浓度，并评估其与HDM致敏、喘息和哮喘的关系，从出生到学龄。在5个地理分布的欧洲出生cohols.MethodsWe包括4334名儿童从INMA-Menorca（西班牙），BAMSE（瑞典），LISAplus和MAS（德国），和PIAMA-NHS（荷兰）。在早期的生活和分析屋尘螨（Der p1）和粉尘螨（Der f1）从卧室收集的灰尘样本。HDM浓度分为四类。通过特异性IgE测定致敏性。通过问卷调查收集8/10岁的喘息和哮喘信息。我们进行了混合效应的logistic回归模型，并表示为比值比与95%的置信区间associations.ResultsHouse尘螨浓度各不相同的队列。平均过敏原浓度在INMA-Menorca（几何平均值（GM）Der p1=3.3g/g）和LISAplus（GM Der f1=2.1g/g）中最高，在BAMSE中最低（GM Der p1=0.1g/g，Der f1=0.3g/g）。中、高HDM浓度组与对照组比较差异有统计学意义（P值
BackgroundExposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma.ObjectiveTo describe the house dust mite (HDM) allergen concentrations in bedroom dust during early life and to evaluate its associations with HDM sensitization, wheezing, and asthma, from birth to school age, in 5 geographically spread European birth cohorts.MethodsWe included 4334 children from INMA-Menorca (Spain), BAMSE (Sweden), LISAplus and MAS (Germany), and PIAMA-NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus (Der p1) and Dermatophagoides farinae (Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific IgE. Wheezing and asthma information up to 8/10years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals.ResultsHouse dust mite concentrations varied across cohorts. Mean allergen concentrations were highest in INMA-Menorca (geometric mean (GM) Der p1=3.3g/g) and LISAplus (GM Der f1=2.1g/g) and lowest in BAMSE (GM Der p1=0.1g/g, Der f1=0.3g/g). Moderate and high HDM concentrations were significantly (P-values